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    pmrA two-component regulator system response regulator PmrA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881834, updated on 11-Sep-2024

    Summary

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    Gene symbol
    pmrA
    Gene description
    two-component regulator system response regulator PmrA
    Locus tag
    PA4776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5364071..5364736)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene two-component regulator system signal sensor kinase PmrB Neighboring gene protein CueR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. McPhee JB, et al. Mol Microbiol, 2003 Oct. PMID 14507375
    2. Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China. Lin J, et al. Antimicrob Agents Chemother, 2019 Oct. PMID 31383654, Free PMC Article
    3. Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa. Ly NS, et al. Antimicrob Agents Chemother, 2012 Jun. PMID 22470116, Free PMC Article
    4. Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. Barrow K, et al. Antimicrob Agents Chemother, 2009 Dec. PMID 19752280, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both colistin resistance and heteroresistance in P. aeruginosa mainly involved alterations of the PmrAB regulatory system.
      Title: Resistance and Heteroresistance to Colistin in Pseudomonas aeruginosa Isolates from Wenzhou, China.
    2. Colistin killing at subinhibitory concentrations was greater against the phoP and pmrA mutants than the wild type within the first 8 h.
      Title: Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa.
    3. Results suggest that polymyxin B resistance among clinical isolates of P. aeruginosa is associated with alterations in two-component regulatory systems of phoPQ or pmrAB.
      Title: Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component regulator system response regulator PmrA
    NP_253464.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5364071..5364736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253464.1 two-component regulator system response regulator PmrA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253464.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0N9QPM1
      Conserved Domains (1) summary
      PRK10336
      Location:1 → 219
      PRK10336; two-component system response regulator QseB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HV32.1

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