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    Ceacam16 CEA cell adhesion molecule 16 [ Mus musculus (house mouse) ]

    Gene ID: 330483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ceacam16provided by MGI
    Official Full Name
    CEA cell adhesion molecule 16provided by MGI
    Primary source
    MGI:MGI:2685615
    See related
    Ensembl:ENSMUSG00000014686 AllianceGenome:MGI:2685615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm769
    Summary
    Predicted to enable identical protein binding activity. Involved in sensory perception of sound. Located in stereocilium tip. Is expressed in brainstem; metanephros; submandibular gland; and testis. Used to study autosomal dominant nonsyndromic deafness 4A. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4B and autosomal recessive nonsyndromic deafness 113. Orthologous to human CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 9.6), CNS E18 (RPKM 2.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ceacam16 in Genome Data Viewer
    Location:
    7 A3; 7 9.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19586022..19595224, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19852097..19871426, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174 Neighboring gene predicted gene, 34891 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20426963-20427193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20429933-20430166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20430230-20430572 Neighboring gene STARR-positive B cell enhancer ABC_E6521 Neighboring gene predicted gene, 19345 Neighboring gene STARR-positive B cell enhancer ABC_E11343 Neighboring gene STARR-seq mESC enhancer starr_18229 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene poliovirus receptor Neighboring gene ribosomal protein L14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Age-related degradation of tectorial membrane dynamics with loss of CEACAM16. Mansour A, et al. Biophys J, 2021 Nov 2. PMID 34555361, Free PMC Article
    2. Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16(βgal/βgal) Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113. Goodyear RJ, et al. Front Mol Neurosci, 2019. PMID 31249509, Free PMC Article
    3. Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions. Cheatham MA, et al. J Neurosci, 2014 Jul 30. PMID 25080593, Free PMC Article
    4. Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. Kammerer R, et al. J Biol Chem, 2012 Jun 22. PMID 22544735, Free PMC Article
    5. Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). Zheng J, et al. Proc Natl Acad Sci U S A, 2011 Mar 8. PMID 21368133, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.
      Title: Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.
    2. The data of this study indicated that CEACAM16 is required for striated-sheet matrix formation. Its continual expression may stabilize the noncollagenous TM matrix.
      Title: Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions.
    3. CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
      Title: Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell adhesion molecule CEACAM16; carcinoembryonic antigen-related cell adhesion molecule 16
    Names
    CEA-related cell adhesion molecule 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033419.2 → NP_001028591.2  cell adhesion molecule CEACAM16 precursor

      See identical proteins and their annotated locations for NP_001028591.2

      Status: VALIDATED

      Source sequence(s)
      AC149085
      Consensus CDS
      CCDS39805.1
      UniProtKB/Swiss-Prot
      B2RUD6, E9QA28
      Related
      ENSMUSP00000014830.8, ENSMUST00000014830.8
      Conserved Domains (3) summary
      cd05774
      Location:24 → 128
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13927
      Location:246 → 298
      Ig_3; Immunoglobulin domain
      cl11960
      Location:140 → 220
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19586022..19595224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242689.2 → XP_030098549.1  carcinoembryonic antigen-related cell adhesion molecule 16 isoform X2

      Conserved Domains (3) summary
      cd05774
      Location:24 → 128
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13927
      Location:246 → 298
      Ig_3; Immunoglobulin domain
      cl11960
      Location:140 → 220
      Ig; Immunoglobulin domain

    2. XM_011250607.4 → XP_011248909.1  carcinoembryonic antigen-related cell adhesion molecule 16 isoform X1

      Conserved Domains (3) summary
      cd05774
      Location:24 → 128
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13927
      Location:246 → 298
      Ig_3; Immunoglobulin domain
      cl11960
      Location:140 → 220
      Ig; Immunoglobulin domain

    3. XM_006540112.5 → XP_006540175.1  carcinoembryonic antigen-related cell adhesion molecule 16 isoform X2

      Conserved Domains (3) summary
      cd05774
      Location:24 → 128
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13927
      Location:246 → 298
      Ig_3; Immunoglobulin domain
      cl11960
      Location:140 → 220
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9QA28.1 GenPept UniProtKB/Swiss-Prot:E9QA28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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