Klf14 Kruppel-like transcription factor 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf14provided by MGI
Official Full Name: Kruppel-like transcription factor 14provided by MGI
Primary source: MGI:MGI:3577024
See related: Ensembl:ENSMUSG00000073209 AllianceGenome:MGI:3577024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BTEB5; 5330411L03Rik
Summary: Enables chromatin binding activity. Acts upstream of or within positive regulation of sphingolipid mediated signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skin. Orthologous to human KLF14 (KLF transcription factor 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.54 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (30932956..30935925, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (30956021..30958990, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning.
Title: Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning.
Downregulation of Kruppel-like factor 14 accelerated cellular senescence and aging.
Title: Downregulation of Krüppel-like factor 14 accelerated cellular senescence and aging.
Hepatic Kruppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
Title: Hepatic Krüppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation.
Title: Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation.
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Title: The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis.
Title: The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis.
Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.
Title: Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.
Kruppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
Title: Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
Klf14 is an imprinted transcription factor that regulates placental growth.
Title: Klf14 is an imprinted transcription factor that regulates placental growth.
Kruppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
Title: Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of sphingolipid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 14

Names: Kruppel-like factor 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135093.1 → NP_001128565.1 Krueppel-like factor 14

See identical proteins and their annotated locations for NP_001128565.1

Status: VALIDATED

Source sequence(s)

AC121800

Consensus CDS

CCDS51744.1

UniProtKB/Swiss-Prot

Q19A41

Related

ENSMUSP00000099122.4, ENSMUST00000101589.5

Conserved Domains (3) summary

COG5048
Location:198 → 283

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:200 → 219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:241 → 266

zf-H2C2_2; Zinc-finger double domain