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    Pag1 phosphoprotein associated with glycosphingolipid microdomains 1 [ Mus musculus (house mouse) ]

    Gene ID: 94212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pag1provided by MGI
    Official Full Name
    phosphoprotein associated with glycosphingolipid microdomains 1provided by MGI
    Primary source
    MGI:MGI:2443160
    See related
    Ensembl:ENSMUSG00000027508 AllianceGenome:MGI:2443160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbp; Pag; F730007C19Rik
    Summary
    Predicted to enable SH2 domain binding activity. Involved in negative regulation of T cell activation. Predicted to be located in plasma membrane. Predicted to be active in membrane raft. Is expressed in several structures, including brain and spinal cord. Orthologous to human PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 20.1), spleen adult (RPKM 7.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pag1 in Genome Data Viewer
    Location:
    3 A1; 3 2.47 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (9752539..9898744, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (9687479..9833684, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 704 Neighboring gene predicted gene, 54189 Neighboring gene STARR-seq mESC enhancer starr_06908 Neighboring gene STARR-seq mESC enhancer starr_06911 Neighboring gene STARR-seq mESC enhancer starr_06917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:9633164-9633347 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:9633637-9633868 Neighboring gene STARR-seq mESC enhancer starr_06923 Neighboring gene STARR-seq mESC enhancer starr_06924 Neighboring gene STARR-seq mESC enhancer starr_06927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:9662928-9663081 Neighboring gene STARR-positive B cell enhancer mm9_chr3:9677144-9677445 Neighboring gene predicted gene, 33169 Neighboring gene stromal cell derived factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06929 Neighboring gene STARR-seq mESC enhancer starr_06930 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:9865803-9866092 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:9887341-9887494 Neighboring gene STARR-positive B cell enhancer mm9_chr3:9892992-9893293 Neighboring gene predicted gene, 33273 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PAG1 limits allergen-induced type 2 inflammation in the murine lung. Ullah MA, et al. Allergy, 2020 Feb. PMID 31321783
    2. Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity. Plani-Lam JH, et al. Exp Hematol, 2017 Feb. PMID 27751872
    3. Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling. Draberova L, et al. Mol Cell Biol, 2014 Dec 1. PMID 25246632, Free PMC Article
    4. The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. Dobenecker MW, et al. Mol Cell Biol, 2005 Dec. PMID 16287865, Free PMC Article
    5. Impairment in a negative regulatory system for TCR signaling in CD4+ T cells from old mice. Inomata M, et al. FEBS Lett, 2007 Jun 26. PMID 17559841

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis.
      Title: CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis.
    2. PAG1 limits allergen-induced type 2 inflammation in the murine lung.
      Title: PAG1 limits allergen-induced type 2 inflammation in the murine lung.
    3. our findings illustrate that Cbp is an important regulator of Csk recruitment to the SFK Lyn in Eporesponsive erythroid cells.
      Title: Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity.
    4. This study demonstrated that cbp increase in skeletal muscle in muscle atrophy.
      Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
    5. PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
      Title: Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells.
    6. If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
      Title: Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase.
    7. PAG can function as both a positive and a negative regulator of mast cell signaling, depending upon the signaling pathway involved. PAG is a positive regulator of passive systemic anaphylaxis.
      Title: Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
    8. Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain.
      Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
    9. Cbp plays a role in adult hematopoietic stem cell homeostasis.
      Title: The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.
    10. regulates epithelial-mesenchymal transition in trophoblast stem cells
      Title: MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoprotein associated with glycosphingolipid-enriched microdomains 1
    Names
    Csk-binding protein
    phosphoprotein transmembrane adaptor 1
    phosphoprotein-associated with GEMs
    transmembrane phosphoprotein Cbp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195031.1 → NP_001181960.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1

      See identical proteins and their annotated locations for NP_001181960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.
      Source sequence(s)
      AC129945, AC156996, AK040230
      Consensus CDS
      CCDS17235.1
      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Related
      ENSMUSP00000124529.2, ENSMUST00000161949.8
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    2. NM_053182.5 → NP_444412.2  phosphoprotein associated with glycosphingolipid-enriched microdomains 1

      See identical proteins and their annotated locations for NP_444412.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants A and B encode the same protein.
      Source sequence(s)
      AC129945, AC156996, AK089329
      Consensus CDS
      CCDS17235.1
      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Related
      ENSMUSP00000104021.3, ENSMUST00000108384.9
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      9752539..9898744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163426.1 → XP_036019319.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    2. XM_011248151.4 → XP_011246453.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

      See identical proteins and their annotated locations for XP_011246453.1

      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    3. XM_030252926.2 → XP_030108786.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    4. XM_006530107.1 → XP_006530170.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1

      See identical proteins and their annotated locations for XP_006530170.1

      UniProtKB/Swiss-Prot
      Q3U1F9, Q8BFS1, Q9EQF3
      UniProtKB/TrEMBL
      A6H659
      Conserved Domains (1) summary
      pfam15347
      Location:2 → 429
      PAG; Phosphoprotein associated with glycosphingolipid-enriched

    5. XM_030252928.1 → XP_030108788.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2

    6. XM_030252927.1 → XP_030108787.1  phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1F9.2 GenPept UniProtKB/Swiss-Prot:Q3U1F9

    Gene LinkOut

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