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    Zfand1 zinc finger, AN1-type domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 66361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfand1provided by MGI
    Official Full Name
    zinc finger, AN1-type domain 1provided by MGI
    Primary source
    MGI:MGI:1913611
    See related
    Ensembl:ENSMUSG00000039795 AllianceGenome:MGI:1913611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310008M20Rik
    Summary
    Predicted to enable proteasome binding activity. Predicted to be involved in cellular response to arsenite ion; positive regulation of intracellular protein transport; and stress granule disassembly. Predicted to be active in cytoplasmic stress granule. Is expressed in bladder; central nervous system; male associated reproductive structure; testis; and urethra of male. Orthologous to human ZFAND1 (zinc finger AN1-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.1), CNS E11.5 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfand1 in Genome Data Viewer
    Location:
    3 A1; 3 2.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10405013..10416383, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10339956..10351334, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene inositol (myo)-1(or 4)-monophosphatase 1 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7900 Neighboring gene STARR-positive B cell enhancer mm9_chr3:10351257-10351557 Neighboring gene STARR-seq mESC enhancer starr_06944 Neighboring gene charged multivesicular body protein 4C Neighboring gene sorting nexin 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. Sá-Moura B, et al. J Biol Chem, 2013 Nov 22. PMID 24121501, Free PMC Article
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107161

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to arsenite ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to arsenite ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress granule disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 1
    Names
    zinc finger AN1-type-containing protein 1
    NP_001317942.1
    NP_001317943.1
    NP_001317944.1
    NP_001385989.1
    NP_001385990.1
    NP_001385991.1
    NP_001385992.1
    NP_079788.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331013.2 → NP_001317942.1  AN1-type zinc finger protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123726
      Consensus CDS
      CCDS89614.1
      UniProtKB/TrEMBL
      D3Z7G5
      Related
      ENSMUSP00000104014.2, ENSMUST00000108377.8

    2. NM_001331014.2 → NP_001317943.1  AN1-type zinc finger protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/TrEMBL
      F7CFT1
      Conserved Domains (1) summary
      pfam01428
      Location:41 → 77
      zf-AN1; AN1-like Zinc finger

    3. NM_001331015.2 → NP_001317944.1  AN1-type zinc finger protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/Swiss-Prot
      Q8BFR6
      Conserved Domains (1) summary
      cl21456
      Location:13 → 84
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    4. NM_001399060.1 → NP_001385989.1  AN1-type zinc finger protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123726
      Conserved Domains (1) summary
      pfam01428
      Location:74 → 110
      zf-AN1; AN1-like Zinc finger

    5. NM_001399061.1 → NP_001385990.1  AN1-type zinc finger protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123726

    6. NM_001399062.1 → NP_001385991.1  AN1-type zinc finger protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/TrEMBL
      F7CFT1
      Conserved Domains (1) summary
      pfam01428
      Location:41 → 77
      zf-AN1; AN1-like Zinc finger

    7. NM_001399063.1 → NP_001385992.1  AN1-type zinc finger protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/TrEMBL
      F7CFT1
      Conserved Domains (1) summary
      pfam01428
      Location:41 → 77
      zf-AN1; AN1-like Zinc finger

    8. NM_025512.4 → NP_079788.2  AN1-type zinc finger protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079788.2

      Status: VALIDATED

      Source sequence(s)
      AC123726
      Consensus CDS
      CCDS17242.1
      UniProtKB/Swiss-Prot
      Q8BFR6, Q8R3Y6, Q9D7H5
      UniProtKB/TrEMBL
      F7CFT1
      Related
      ENSMUSP00000037459.6, ENSMUST00000037839.12
      Conserved Domains (2) summary
      pfam01428
      Location:10 → 46
      zf-AN1; AN1-like Zinc finger
      cl21456
      Location:120 → 191
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      10405013..10416383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFR6.1 GenPept UniProtKB/Swiss-Prot:Q8BFR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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