Prl3c1 prolactin family 3, subfamily c, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl3c1provided by MGI
Official Full Name: prolactin family 3, subfamily c, member 1provided by MGI
Primary source: MGI:MGI:1351649
See related: Ensembl:ENSMUSG00000017922 AllianceGenome:MGI:1351649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd7; PLP-I; PLP-J; Prlpi; Prlpj; decidualin
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in decidua; extraembryonic component; placenta; and uterus stroma. Used to study hyperandrogenism. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 2.5) See more
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Genomic context

Location:: 13 A3.1; 13 12.32 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (27380643..27387732)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (27196660..27203749)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the biology of the Prl3c1 gene has provided insight into a previously unappreciated homeostatic setpoint control system programming testicular growth and function.
Title: Origin of a rapidly evolving homeostatic control system programming testis function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

AI429535 (e-PCR)
- UniSTS:160279

NoName (e-PCR)
- UniSTS:492599

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin-3C1

Names: PLP I; PRL-like protein I; PRL-like protein J; growth hormone d7; placental prolactin-like protein J; prolactin-like protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163218.1 → NP_001156690.1 prolactin-3C1 isoform 2

See identical proteins and their annotated locations for NP_001156690.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AF234637, AK014980, AL589679

Consensus CDS

CCDS49223.1

UniProtKB/TrEMBL

Z4YL38

Related

ENSMUSP00000105993.2, ENSMUST00000110364.9

Conserved Domains (1) summary

cd10288
Location:3 → 189

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
NM_013766.2 → NP_038794.1 prolactin-3C1 isoform 1 precursor

See identical proteins and their annotated locations for NP_038794.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF234637

Consensus CDS

CCDS26392.1

UniProtKB/Swiss-Prot

Q5SZY4, Q9QUN5

UniProtKB/TrEMBL

Q0VBM3

Related

ENSMUSP00000018066.7, ENSMUST00000018066.13

Conserved Domains (1) summary

cd10288
Location:23 → 209

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones