Tmx1 thioredoxin-related transmembrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmx1provided by MGI
Official Full Name: thioredoxin-related transmembrane protein 1provided by MGI
Primary source: MGI:MGI:1919986
See related: Ensembl:ENSMUSG00000021072 AllianceGenome:MGI:1919986
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Txndc1; 2810425A04Rik
Summary: Enables protein disulfide isomerase activity. Involved in negative regulation of platelet aggregation. Predicted to be located in extracellular region and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 28.3), placenta adult (RPKM 26.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C2; 12 29.13 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (70499928..70514398)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (70453154..70467624)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMX1 as an oxidative stress protective factor.
Title: Characterization of Naïve and Vitamin C-Treated Mouse Schwann Cell Line MSC80: Induction of the Antioxidative Thioredoxin Related Transmembrane Protein 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein disulfide isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-related transmembrane protein 1

Names: protein disulfide-isomerase TMX1; thioredoxin domain containing 1; thioredoxin domain-containing protein 1

NP_082615.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028339.1 → NP_082615.1 thioredoxin-related transmembrane protein 1 precursor

See identical proteins and their annotated locations for NP_082615.1

Status: PROVISIONAL

Source sequence(s)

BC017603

Consensus CDS

CCDS25958.1

UniProtKB/Swiss-Prot

Q3UCI8, Q8VBT0, Q9CSD5

Related

ENSMUSP00000021471.7, ENSMUST00000021471.13

Conserved Domains (1) summary

cd02994
Location:30 → 129

PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...