Acmsd amino carboxymuconate semialdehyde decarboxylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acmsdprovided by MGI
Official Full Name: amino carboxymuconate semialdehyde decarboxylaseprovided by MGI
Primary source: MGI:MGI:2386323
See related: Ensembl:ENSMUSG00000026348 AllianceGenome:MGI:2386323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable aminocarboxymuconate-semialdehyde decarboxylase activity and zinc ion binding activity. Predicted to be involved in negative regulation of quinolinate biosynthetic process; secondary metabolic process; and tryptophan catabolic process. Predicted to act upstream of or within quinolinate metabolic process. Predicted to be active in cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 20.8), liver adult (RPKM 2.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E3; 1 55.8 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (127657149..127695723)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (127729413..127767564)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), the enzyme that limits spontaneous cyclization of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde in the de novo NAD(+) synthesis pathway, controls cellular NAD(+) levels via an evolutionarily conserved mechanism in Caenorhabditis elegans and mouse
Title: De novo NAD(+) synthesis enhances mitochondrial function and improves health.
These results indicate that PGC1alpha is involved in Acmsd expression through cooperation with HNF4alpha.
Title: PGC1α regulates ACMSD expression through cooperation with HNF4α.
Acmsd gene expression was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxisome proliferator-activated receptor alpha (PPARalpha).
Title: Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminocarboxymuconate-semialdehyde decarboxylase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables aminocarboxymuconate-semialdehyde decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of quinolinate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of quinolinate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within quinolinate metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in secondary metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophan catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Names: picolinate carboxylase

NP_001028213.1

EC 4.1.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.