Dock4 dedicator of cytokinesis 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dock4provided by RGD
Official Full Name: dedicator of cytokinesis 4provided by RGD
Primary source: RGD:1561724
See related: EnsemblRapid:ENSRNOG00000004823 AllianceGenome:RGD:1561724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 188.1), Brain (RPKM 147.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (63240050..63629772)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (57512929..57902597)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (60374839..60782648)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury.
Title: Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury.
a new function of the Rac activator Dock4 in dendritic morphogenesis in hippocampal neurons
Title: Dock4 regulates dendritic development in hippocampal neurons.
Dock4 is highly concentrated in dendritic spines and implicated in spine formation via interaction with the actin-binding protein cortactin.
Title: Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.

Submit: New GeneRIF Correction

General gene information

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Markers

D6Mit4 (e-PCR), detects polymorphism
- UniSTS:119600

AU047538 (e-PCR)
- UniSTS:110410

BF403292 (e-PCR)
- UniSTS:246376

BE120673 (e-PCR)
- UniSTS:247412

D6Rat58 (e-PCR), detects polymorphism
- UniSTS:228067

D6Got73 (e-PCR)
- UniSTS:112373

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427091.1 → NP_001414020.1 dedicator of cytokinesis protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZNR8

Related

ENSRNOP00000079532.1, ENSRNOT00000110069.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

63240050..63629772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078130.2 → XP_038934058.1 dedicator of cytokinesis protein 4 isoform X5

UniProtKB/TrEMBL

A6HBD9

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus

cl06123
Location:1187 → 1227

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_039078128.2 → XP_038934056.1 dedicator of cytokinesis protein 4 isoform X3

UniProtKB/TrEMBL

F1LZ81

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_039078129.2 → XP_038934057.1 dedicator of cytokinesis protein 4 isoform X4

UniProtKB/TrEMBL

F1LZ81, M0R6K4

Related

ENSRNOP00000065056.3, ENSRNOT00000075193.4

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_039078126.2 → XP_038934054.1 dedicator of cytokinesis protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I5ZXG8, F1LZ81

Related

ENSRNOP00000083690.1, ENSRNOT00000112020.2

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_039078125.1 → XP_038934053.1 dedicator of cytokinesis protein 4 isoform X1

UniProtKB/TrEMBL

F1LZ81

Related

ENSRNOP00000006709.8, ENSRNOT00000006709.10

Conserved Domains (4) summary

cd08695
Location:399 → 583

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1205 → 1595

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:9 → 64

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:68 → 391

DOCK_N; DOCK N-terminus