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    Etv1 ETS variant transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Etv1provided by RGD
    Official Full Name
    ETS variant transcription factor 1provided by RGD
    Primary source
    RGD:1312007
    See related
    EnsemblRapid:ENSRNOG00000006867 AllianceGenome:RGD:1312007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including axon guidance; mechanosensory behavior; and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 239.6), Adrenal (RPKM 84.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etv1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (61316836..61408985)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (55590149..55681784)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (58467215..58558640)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, beta Neighboring gene uncharacterized LOC134479368 Neighboring gene phosphatidylethanolamine binding protein 1, pseudogene 2 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 9 Neighboring gene uncharacterized LOC120103524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes. Shekhar A, et al. Sci Rep, 2018 Jul 2. PMID 29967479, Free PMC Article
    2. Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis. Yang L, et al. Biol Reprod, 2006 Apr. PMID 16394217
    3. Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter. Pastorcic M, et al. Brain Res Mol Brain Res, 2003 May 12. PMID 12750007
    4. Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. Firlej V, et al. J Biol Chem, 2005 Jan 14. PMID 15466854
    5. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Arber S, et al. Cell, 2000 May 26. PMID 10850491

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mechanosensory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS translocation variant 1
    Names
    ets variant gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108709.3 → NP_001102179.2  ETS translocation variant 1 isoform b

      See identical proteins and their annotated locations for NP_001102179.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      BC168860, BQ195622, JAXUCZ010000006
      UniProtKB/TrEMBL
      B5DEZ2
      Related
      ENSRNOP00000059718.1, ENSRNOT00000065396.5
      Conserved Domains (2) summary
      smart00413
      Location:311 → 395
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:1 → 310
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    2. NM_001163156.3 → NP_001156628.1  ETS translocation variant 1 isoform a

      See identical proteins and their annotated locations for NP_001156628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC168860, BQ195622, CB547717, CB718897, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JTM3, B5DEZ2
      Conserved Domains (2) summary
      smart00413
      Location:334 → 418
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2 → 333
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      61316836..61408985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262098.1 → XP_063118168.1  ETS translocation variant 1 isoform X2

    2. XM_063262097.1 → XP_063118167.1  ETS translocation variant 1 isoform X2

    3. XM_008764648.4 → XP_008762870.1  ETS translocation variant 1 isoform X4

      See identical proteins and their annotated locations for XP_008762870.1

      UniProtKB/TrEMBL
      B5DEZ2
      Conserved Domains (2) summary
      smart00413
      Location:311 → 395
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:1 → 310
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    4. XM_063262096.1 → XP_063118166.1  ETS translocation variant 1 isoform X1

      Related
      ENSRNOP00000101720.1, ENSRNOT00000146193.1

    5. XM_008764647.3 → XP_008762869.1  ETS translocation variant 1 isoform X3

      Conserved Domains (2) summary
      smart00413
      Location:324 → 408
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:28 → 323
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    6. XM_063262100.1 → XP_063118170.1  ETS translocation variant 1 isoform X6

    7. XM_063262099.1 → XP_063118169.1  ETS translocation variant 1 isoform X5

      Related
      ENSRNOP00000110357.1, ENSRNOT00000138494.1
    Nucleotide Protein Strain
    Heading Accession and Version

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