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    Dhrs4 Dehydrogenase/reductase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs4provided by FlyBase
    Official Full Name
    Dehydrogenase/reductase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035588
    Locus tag
    Dmel_CG10672
    See related
    AllianceGenome:FB:FBgn0035588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10672; DHRS4; DHSR4; Dmel\CG10672; dPECR; PECR
    Summary
    Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be located in peroxisome. Is expressed in adult head; adult heart; embryonic midgut chamber; embryonic/larval midgut; and organism. Orthologous to several human genes including DHRS2 (dehydrogenase/reductase 2) and DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhrs4 in Genome Data Viewer
    Location:
    64C7-64C7; 3-13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5140440..5141646, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5133540..5134746, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45160 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Threonyl-carbamoyl synthesis 5 Neighboring gene Charged multivesicular body protein 2b Neighboring gene long non-coding RNA:CR45985 Neighboring gene Gdap1 Neighboring gene Fat storage inducing transmembrane protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERR and dPECR Suggest a Link Between Neuroprotection and the Regulation of Ethanol Consumption Preference. Velo Escarcena L, et al. Front Psychiatry, 2021. PMID 33981260, Free PMC Article
    2. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
    3. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
    4. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. Gabrielli F, et al. Gene, 2012 Dec 15. PMID 23036705
    5. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This locus represents the D. melanogaster DHRS4 gene, which is the ortholog of the human DHRS4 gene.
      Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dehydrogenase/reductase 4
    Names
    CG10672-PA
    Dhrs4-PA
    peroxisomal trans-2-enoyl-CoA reductase
    NP_647946.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5140440..5141646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139689.3 → NP_647946.1  Dehydrogenase/reductase 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRJ4
      Related
      FBpp0076882
      Conserved Domains (2) summary
      PRK07231
      Location:67 → 316
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
      cl21454
      Location:67 → 317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRJ4 Q9VRJ4

    Gene LinkOut

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