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    CG10863 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10863provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027552
    Locus tag
    Dmel_CG10863
    See related
    AllianceGenome:FB:FBgn0027552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10614; dm1/AKR2E3; Dmel\CG10863
    Summary
    Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in cytosol. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10863 in Genome Data Viewer
    Location:
    64A1-64A1; 3-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3941008..3942465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3941008..3942465, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43916 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Duque P, et al. Genes (Basel), 2022 Oct 21. PMID 36292802, Free PMC Article
    2. Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Di Luccio E, et al. Biochem J, 2006 Nov 15. PMID 16813561, Free PMC Article
    3. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
    4. Drosophila ventral furrow morphogenesis: a proteomic analysis. Gong L, et al. Development, 2004 Feb. PMID 14711877
    5. Proteomic characterization of inbreeding-related cold sensitivity in Drosophila melanogaster. Vermeulen CJ, et al. PLoS One, 2013. PMID 23658762, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10863-PA
    NP_647840.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3941008..3942465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139583.4 → NP_647840.1  uncharacterized protein Dmel_CG10863 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3L7, Q9Y112
      Related
      FBpp0073028
      Conserved Domains (2) summary
      COG0656
      Location:6 → 304
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 290
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y112 Q9Y112

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