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    Ms Myosuppressin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msprovided by FlyBase
    Official Full Name
    Myosuppressinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011581
    Locus tag
    Dmel_CG6440
    See related
    AllianceGenome:FB:FBgn0011581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6440; CG6440; Dm-MS; Dmel\CG6440; dms; Dms; DMS; Drm-MS; Drome-MS; FLRFa; MEMS; MS; Nems
    Summary
    Enables neuropeptide receptor binding activity. Involved in several processes, including adult locomotory behavior; negative regulation of heart rate; and neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including DMS neuron; adult brain; central nervous system; crop; and embryonic central brain neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    95F14-95F14; 3-84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24341551..24343825)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20167273..20169547)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dis3 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Golgin-84

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal expression identify dromyosuppressin as a brain-gut peptide in Drosophila melanogaster. McCormick J, et al. J Comp Neurol, 1993 Dec 8. PMID 8308172
    2. Mating regulates neuromodulator ensembles at nerve termini innervating the Drosophila reproductive tract. Heifetz Y, et al. Curr Biol, 2014 Mar 31. PMID 24631240, Free PMC Article
    3. Structure-activity and immunochemical data provide evidence of developmental- and tissue-specific myosuppressin signaling. Dickerson M, et al. Peptides, 2012 Aug. PMID 22613084, Free PMC Article
    4. A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions. Mispelon M, et al. Peptides, 2003 Oct. PMID 14706539
    5. Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction. Hewes RS, et al. J Neurosci, 1998 Sep 15. PMID 9736637, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of digestive system process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of heart contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myosuppressin
    Names
    CG6440-PA
    CG6440-PB
    CG6440-PC
    Drm-myosuppressin
    Ms-PA
    Ms-PB
    Ms-PC
    TDVDHVFLRFamide
    dromyosuppressin
    neomyosuppressin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24341551..24343825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300574.1 → NP_001287503.1  myosuppressin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41494, P61849, Q9VC91
      UniProtKB/TrEMBL
      A0A0B4KGT7

    2. NM_080511.3 → NP_536772.1  myosuppressin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41494, P61849, Q9VC91
      UniProtKB/TrEMBL
      A0A0B4KGT7
      Related
      FBpp0083991

    3. NM_001275982.1 → NP_001262911.1  myosuppressin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41494, P61849, Q9VC91
      UniProtKB/TrEMBL
      A0A0B4KGT7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGT7 A0A0B4KGT7
    P61849.1 P61849

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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