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    Hcs Holocarboxylase synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hcsprovided by FlyBase
    Official Full Name
    Holocarboxylase synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037332
    Locus tag
    Dmel_CG14670
    See related
    AllianceGenome:FB:FBgn0037332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14670; Dmel\CG14670; HCS; HSC; NEST:bs27h05
    Summary
    Enables biotin--[biotin carboxyl-carrier protein] ligase activity. Involved in chromatin organization and regulation of DNA-templated transcription. Is active in nucleus. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hcs in Genome Data Viewer
    Location:
    83A5-83A5; 3-47.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5474899..5485393)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1300621..1311115)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Snf5-related 1 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 3 Neighboring gene kinase suppressor of ras Neighboring gene uncharacterized protein Neighboring gene sodium potassium chloride cotransporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster. Reyes-Carmona S, et al. Mol Genet Metab, 2011 Jul. PMID 21463962
    2. Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. Camporeale G, et al. J Nutr, 2006 Nov. PMID 17056793, Free PMC Article
    3. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Lohr KM, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33318181, Free PMC Article
    4. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. Camporeale G, et al. J Nutr, 2007 Apr. PMID 17374649, Free PMC Article
    5. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HCS may have a role in the repression of gene expression through a mechanism involving its trafficking to the nucleus and interaction with heterochromatic sites coincident with H3K9met3.
      Title: Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster.
    2. Gene expression patterns and phenotypes in holocarboxylase synthetase-deficient flies in previous studies are caused by decreased biotinylation of histones, not 3-methylcrotonyl-CoA carboxylase.
      Title: Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    holocarboxylase synthetase
    Names
    CG14670-PA
    CG14670-PB
    CG14670-PC
    CG14670-PD
    Hcs-PA
    Hcs-PB
    Hcs-PC
    Hcs-PD
    NP_001262284.1
    NP_001287175.1
    NP_001287176.1
    NP_649542.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5474899..5485393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300246.1 → NP_001287175.1  holocarboxylase synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGM5
      Conserved Domains (5) summary
      COG0340
      Location:812 → 1037
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:988 → 1037
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:293 → 437
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:456 → 509
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:793 → 921
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    2. NM_141285.2 → NP_649542.1  holocarboxylase synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNC3
      Related
      FBpp0078332
      Conserved Domains (5) summary
      COG0340
      Location:806 → 1031
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:982 → 1031
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:293 → 437
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:456 → 509
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:787 → 915
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    3. NM_001300247.1 → NP_001287176.1  holocarboxylase synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGS6
      Conserved Domains (5) summary
      COG0340
      Location:764 → 989
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:940 → 989
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:245 → 389
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:408 → 461
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:745 → 873
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    4. NM_001275355.1 → NP_001262284.1  holocarboxylase synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF92
      Conserved Domains (5) summary
      COG0340
      Location:758 → 983
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:934 → 983
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:245 → 389
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:408 → 461
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:739 → 867
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF92 A0A0B4KF92
    A0A0B4LGM5 A0A0B4LGM5
    A0A0B4LGS6 A0A0B4LGS6
    Q9VNC3 Q9VNC3

    Gene LinkOut

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