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    crq croquemort [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crqprovided by FlyBase
    Official Full Name
    croquemortprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015924
    Locus tag
    Dmel_CG4280
    See related
    AllianceGenome:FB:FBgn0015924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.8; Cd36; CD36; CG31655; CG4280; cqm; cqr; Cqr; Croquemort; Crq; CRQ; D-CD36; Dmel\CG4280
    Summary
    Predicted to enable scavenger receptor activity. Involved in several processes, including defense response to protozoan; phagocytosis; and phagosome maturation. Located in membrane. Is expressed in several structures, including circulatory system primordium; gland; gonad; hemocyte; and nephrocyte. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crq in Genome Data Viewer
    Location:
    21C2-21C2; 2-0.7 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (448254..453024, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (448254..453024, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 8 Neighboring gene expanded Neighboring gene long non-coding RNA:CR43717 Neighboring gene pseudo Neighboring gene shriveled

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Franc NC, et al. Immunity, 1996 May. PMID 8630729
    2. Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper. Tung TT, et al. J Biochem, 2013 May. PMID 23420848
    3. An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy. Poels J, et al. Autophagy, 2012 Sep. PMID 22885706, Free PMC Article
    4. Recognizing death: the phagocytosis of apoptotic cells. Platt N, et al. Trends Cell Biol, 1998 Sep. PMID 9728398
    5. The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryos. Tingvall TO, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274409, Free PMC Article

    See all (198) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster.
      Title: bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster.
    2. our data demonstrate that Crq plays a key role in maintaining immune and organismal homeostasis
      Title: The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging.
    3. results show highly regulated expression patterns, with three genes crq, pes and Snmp being upregulated in steroidogenic tissues at the onset of pupariation when steroidogenesis is crucial
      Title: Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c451692-451600 mobile_element_type = transposon:INE-1{}5702

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in engulfment of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    croquemort
    Names
    CD36-like
    CG4280-PA
    CG4280-PB
    CG4280-PC
    CG4280-PD
    CG4280-PE
    crq-PA
    crq-PB
    crq-PC
    crq-PD
    crq-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      448254..453024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272896.1 → NP_001259825.1  croquemort, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259825.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX7, Q27367, Q8SZG1, Q9VPQ1
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 470
      CD36; CD36 family

    2. NM_175943.2 → NP_787957.1  croquemort, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX7, Q27367, Q8SZG1, Q9VPQ1
      Related
      FBpp0077747
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 470
      CD36; CD36 family

    3. NM_175944.3 → NP_787958.1  croquemort, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX7, Q27367, Q8SZG1, Q9VPQ1
      Related
      FBpp0077748
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 470
      CD36; CD36 family

    4. NM_001272895.1 → NP_001259824.1  croquemort, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX7, Q27367, Q8SZG1, Q9VPQ1
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 470
      CD36; CD36 family

    5. NM_001258894.1 → NP_001245823.1  croquemort, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX7, Q27367, Q8SZG1, Q9VPQ1
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 470
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27367.3 Q27367

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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