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    app approximated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39399, updated on 17-Dec-2024

    Summary

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    Official Symbol
    appprovided by FlyBase
    Official Full Name
    approximatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260941
    Locus tag
    Dmel_CG42318
    See related
    AllianceGenome:FB:FBgn0260941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    App; APP; CG17144; CG42318; CG5620; CR32097; Dmel\CG42318
    Old locus tag
    Dmel_CG17144; Dmel_CG5620
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in establishment of body hair or bristle planar orientation; establishment of imaginal disc-derived wing hair orientation; and pattern specification process. Located in apical cortex and endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval gut; germ layer; and somatic muscle cell. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Orthologous to several human genes including ZDHHC14 (zinc finger DHHC-type palmitoyltransferase 14) and ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See app in Genome Data Viewer
    Location:
    69A2-69A4; 3-38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12206238..12266841, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12199338..12259941, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenylate kinase 1 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase Neighboring gene Spermine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila. Zhao XL, et al. J Neurosci, 2010 Jan 27. PMID 20107079, Free PMC Article
    2. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Branco AT, et al. Heredity (Edinb), 2017 Mar. PMID 27731328, Free PMC Article
    3. The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat. Matakatsu H, et al. J Cell Biol, 2017 Jan 2. PMID 28031421, Free PMC Article
    4. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Matakatsu H, et al. Curr Biol, 2008 Sep 23. PMID 18804377, Free PMC Article
    5. Cytological location and further characterization of the Third chromosome resistance gene in Drosophila melanogaster. Bishop CP, et al. Genetica, 1999. PMID 10568256

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Concomitant loss of early girl and approximated results in accumulation of Dachs and Vamana in cytoplasmic punctae, suggesting that it also regulates their trafficking to the apical membrane.
      Title: Early girl is a novel component of the Fat signaling pathway.
    2. App promotes drosophila growth via the Hippo pathway by palmitoylation of Fat protein.
      Title: The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.
    3. Consistent with its role in Psn processing, hibris genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
      Title: Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
    4. These results suggest that Abeta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits.
      Title: Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of body hair or bristle planar orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    approximated
    Names
    CG42318-PH
    CG42318-PI
    CG42318-PJ
    CG42318-PK
    CG42318-PL
    CG42318-PM
    CG42318-PO
    CG42318-PR
    CG42318-PS
    CG42318-PT
    app-PH
    app-PI
    app-PJ
    app-PK
    app-PL
    app-PM
    app-PO
    app-PR
    app-PS
    app-PT
    NP_001137936.1
    NP_001137937.1
    NP_001137938.2
    NP_001137939.2
    NP_001246731.2
    NP_001246732.1
    NP_001246733.2
    NP_001287043.1
    NP_648561.2
    NP_996065.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12206238..12266841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259803.2 → NP_001246732.1  approximated, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLJ6
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 270
      DHHC; DHHC palmitoyltransferase

    2. NM_001144465.2 → NP_001137937.1  approximated, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEY9, B7Z0A6, M9NDQ1, M9NF95
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 272
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_001144464.2 → NP_001137936.1  approximated, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEY9, B7Z0A6, M9NDQ1, M9NF95
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 272
      zf-DHHC; DHHC palmitoyltransferase

    4. NM_001300114.1 → NP_001287043.1  approximated, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEY9, B7Z0A6, M9NDQ1, M9NF95
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 272
      zf-DHHC; DHHC palmitoyltransferase

    5. NM_001259802.2 → NP_001246731.2  approximated, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246731.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEY9, B7Z0A6, M9NDQ1, M9NF95
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 272
      zf-DHHC; DHHC palmitoyltransferase

    6. NM_001259804.2 → NP_001246733.2  approximated, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246733.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEY9
      Conserved Domains (1) summary
      cl19890
      Location:18 → 53
      zf-DHHC; DHHC palmitoyltransferase

    7. NM_140304.7 → NP_648561.2  approximated, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648561.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTV6
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 270
      zf-DHHC; DHHC palmitoyltransferase

    8. NM_206343.5 → NP_996065.2  approximated, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996065.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTV6
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 270
      zf-DHHC; DHHC palmitoyltransferase

    9. NM_001144467.3 → NP_001137939.2  approximated, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLJ6
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 270
      zf-DHHC; DHHC palmitoyltransferase

    10. NM_001144466.3 → NP_001137938.2  approximated, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLJ6
      Conserved Domains (1) summary
      pfam01529
      Location:146 → 270
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VEY9.1 A2VEY9
    Q8SY85 Q8SY85
    Q9VTV6 Q9VTV6

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