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    CG17985 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17985provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033199
    Locus tag
    Dmel_CG17985
    See related
    AllianceGenome:FB:FBgn0033199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17985
    Summary
    Enables peptidoglycan binding activity. Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in Golgi membrane. Is expressed in adult head. Orthologous to several human genes including LYSMD3 (LysM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17985 in Genome Data Viewer
    Location:
    43E7-43E7; 2-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7651625..7655302, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3539130..3542807, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44444 Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695
    2. Peptidoglycan recognition in Drosophila is mediated by LysMD3/4. Snee M, et al. J Biol Chem, 2023 Jun. PMID 37116706, Free PMC Article
    3. Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations. Mateo L, et al. Sci Rep, 2018 Nov 1. PMID 30385770, Free PMC Article
    4. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article
    5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peptidoglycan recognition in Drosophila is mediated by LysMD3/4.
      Title: Peptidoglycan recognition in Drosophila is mediated by LysMD3/4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17985-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7651625..7655302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136461.4 → NP_610305.1  uncharacterized protein Dmel_CG17985 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4J7
      Related
      FBpp0088020
      Conserved Domains (2) summary
      COG1388
      Location:60 → 105
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:59 → 102
      LysM; LysM domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4J7 Q7K4J7

    Gene LinkOut

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