U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cht2 Chitinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38223, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cht2provided by FlyBase
    Official Full Name
    Chitinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0022702
    Locus tag
    Dmel_CG2054
    See related
    AllianceGenome:FB:FBgn0022702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2054; Cht; Cht-2; cht2; CHT2; DmCht2; DmCHT2; Dmel\CG2054
    Summary
    Enables chitinase activity. Involved in several processes, including chitin catabolic process; chitin-based cuticle development; and ecdysis, chitin-based cuticle. Located in external side of apical plasma membrane and extracellular space. Is expressed in several structures, including adult head; embryonic head epidermis; epidermis; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cht2 in Genome Data Viewer
    Location:
    62B1-62B1; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1752328..1755934, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1752328..1755934, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W b Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 62B Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila Chitinase 2 is expressed in chitin producing organs for cuticle formation. Pesch YY, et al. Arthropod Struct Dev, 2017 Jan. PMID 27832982
    2. Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila. de la Vega H, et al. Insect Mol Biol, 1998 Aug. PMID 9662472
    3. Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis. Petkau G, et al. J Biol Chem, 2012 Jun 15. PMID 22544743, Free PMC Article
    4. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
    5. Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response. Everman ER, et al. Evolution, 2018 Feb. PMID 29214647

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    chitinase 2
    Names
    CG2054-PA
    CG2054-PB
    CG2054-PC
    Cht2-PA
    Cht2-PB
    Cht2-PC
    NP_001246550.1
    NP_001261282.1
    NP_477298.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1752328..1755934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259621.2 → NP_001246550.1  chitinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17421, Q9W092
      UniProtKB/TrEMBL
      D0IQG7
      Conserved Domains (2) summary
      cd02872
      Location:43 → 428
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:42 → 389
      Glyco_18; Glyco_18 domain

    2. NM_001274353.1 → NP_001261282.1  chitinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261282.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17421, Q9W092
      UniProtKB/TrEMBL
      D0IQG7
      Conserved Domains (2) summary
      cd02872
      Location:43 → 428
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:42 → 389
      Glyco_18; Glyco_18 domain

    3. NM_057950.4 → NP_477298.2  chitinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477298.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17421, Q9W092
      UniProtKB/TrEMBL
      D0IQG7
      Related
      FBpp0072677
      Conserved Domains (2) summary
      cd02872
      Location:43 → 428
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:42 → 389
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0IQG7 D0IQG7
    Q9W092.1 Q9W092

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous