Cont Contactin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Contprovided by FlyBase
Official Full Name: Contactinprovided by FlyBase
Primary source: FLYBASE:FBgn0037240
Locus tag: Dmel_CG1084
See related: AllianceGenome:FB:FBgn0037240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1084; cont; CONT; CT1481; D-Axonin; DCONT; Dmel\CG1084
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in cell adhesion involved in heart morphogenesis; nervous system development; and septate junction assembly. Located in septate junction. Is expressed in several structures, including adult head; adult heart; follicle cell; gut section; and sensory organ cell. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy and familial adult myoclonic epilepsy 5. Orthologous to several human genes including CNTN4 (contactin 4) and CNTN6 (contactin 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4381306..4387018)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (207028..212740)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin.
Title: A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions.
Data show that the lateral mobility of cell adhesion molecules neurexin IV, neuroglian, and contactin is highly restricted at septate junctions in Drosophila.
Title: The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila.
Required for organization of septate junctions (SJs) and paracellular barrier function.
Title: Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of glial blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IC Inferred by Curator more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain