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    Nxf3 Nuclear export factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nxf3provided by FlyBase
    Official Full Name
    Nuclear export factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0263232
    Locus tag
    Dmel_CG32135
    See related
    AllianceGenome:FB:FBgn0263232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32135; Dmel\CG32135; nxf3; NXF3
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Orthologous to human NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nxf3 in Genome Data Viewer
    Location:
    70C7-70C9; 3-41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13965203..13973067)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13958303..13966167)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Meiotic central spindle Neighboring gene short spindle 2 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 cognate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes. Głuszek AA, et al. J Cell Biol, 2015 Dec 21. PMID 26668329, Free PMC Article
    2. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis. Lin Y, et al. J Cell Biol, 2023 Oct 2. PMID 37555815, Free PMC Article
    3. To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma. Wang S, et al. Biochem Soc Trans, 2021 Nov 1. PMID 34643228
    4. The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters. Baumgartner L, et al. Elife, 2022 Oct 4. PMID 36193674, Free PMC Article
    5. TEMPLE: analysing population genetic variation at transcription factor binding sites. Litovchenko M, et al. Mol Ecol Resour, 2016 Nov. PMID 27106869

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nxf3 promotes export of piRNA cluster transcripts to cytoplasmic processing sites
      Title: Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • transcript and protein products are distinct from overlapping gene

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear export factor 3
    Names
    CG32135-PD
    CG32135-PE
    Nxf3-PD
    Nxf3-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13965203..13973067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300135.1 → NP_001287064.2  nuclear export factor 3, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW3, Q8IQK4
      Conserved Domains (3) summary
      sd00035
      Location:191 → 231
      LRR_NTF; leucine-rich repeat [structural motif]
      cd21340
      Location:192 → 296
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl09109
      Location:338 → 489
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. NM_168566.2 → NP_729938.2  nuclear export factor 3, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW3, Q8IQK4
      Conserved Domains (3) summary
      sd00035
      Location:191 → 231
      LRR_NTF; leucine-rich repeat [structural motif]
      cd21340
      Location:192 → 296
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl09109
      Location:338 → 489
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQK4 Q8IQK4

    Gene LinkOut

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