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    Try29F Trypsin 29F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Try29Fprovided by FlyBase
    Official Full Name
    Trypsin 29Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015316
    Locus tag
    Dmel_CG9564
    See related
    AllianceGenome:FB:FBgn0015316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9564; Dmel\CG9564; SP106; try29F; try29F.2; trypsin29F
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Try29F in Genome Data Viewer
    Location:
    29F7-29F7; 2-34 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8998537..8999816)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8998537..8999816)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alien Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rcd-1 related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Try29F, a new member of the Drosophila trypsin-like protease gene family, is specifically expressed in the posterior embryonic midgut. Paululat A. Gene, 1996 Jun 26. PMID 8682311
    2. The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein. Paululat A, et al. J Cell Biol, 1997 Jul 28. PMID 9230076, Free PMC Article
    3. The Drosophila gene alien is expressed in the muscle attachment sites during embryogenesis and encodes a protein highly conserved between plants, Drosophila and vertebrates. Goubeaud A, et al. Mech Dev, 1996 Jun. PMID 8817453
    4. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Wang M, et al. Dev Cell, 2022 May 23. PMID 35512700
    5. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trypsin 29F
    Names
    CG9564-PC
    CG9564-PD
    Try29F-PC
    Try29F-PD
    NP_001285772.1
    NP_523518.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8998537..8999816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298843.1 → NP_001285772.1  trypsin 29F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DMZ7, Q9VLF5
      Conserved Domains (2) summary
      smart00020
      Location:41 → 261
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 264
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_078794.3 → NP_523518.2  trypsin 29F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523518.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DMZ7, Q9VLF5
      Related
      FBpp0290879
      Conserved Domains (2) summary
      smart00020
      Location:41 → 261
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 264
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24091 Q24091
    Q9VLF5 Q9VLF5

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