CG11109 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG11109provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037200
Locus tag: Dmel_CG11109
See related: AllianceGenome:FB:FBgn0037200
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CT31087; Dmel\CG11109
Summary: Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in RNA methylation and tRNA modification. Is expressed in organism and spermatozoon. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 82. Orthologous to human NSUN6 (NOP2/Sun RNA methyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80B1-80B1; 3-47 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22872200..22873702)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22865300..22866802)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine-5-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG11109-PA; CG11109-PB

NP_649425.1

EC 2.1.1.-

NP_730761.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

22872200..22873702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168974.2 → NP_730761.1 uncharacterized protein Dmel_CG11109, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730761.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NNV8, Q8IPS4

Related

FBpp0078203

Conserved Domains (3) summary

smart00359
Location:102 → 171

PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase

COG0144
Location:207 → 439

RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

cl17173
Location:222 → 437

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_141168.3 → NP_649425.1 uncharacterized protein Dmel_CG11109, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649425.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VNQ1

Related

FBpp0078204

Conserved Domains (3) summary

smart00359
Location:21 → 90

PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase

COG0144
Location:126 → 358

RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

cl17173
Location:141 → 356

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...