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    Tango1 Transport and Golgi organization 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33930, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tango1provided by FlyBase
    Official Full Name
    Transport and Golgi organization 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0286898
    Locus tag
    Dmel_CG11098
    See related
    AllianceGenome:FB:FBgn0286898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2L3443; CG11098; Dmel\CG11098; tango1; TANGO1
    Summary
    Involved in several processes, including Golgi organization; protein secretion; and secretory granule organization. Located in Golgi cis cisterna and endoplasmic reticulum exit site. Is expressed in adult head and follicle cell. Orthologous to several human genes including MIA2 (MIA SH3 domain ER export factor 2) and MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Tango1 in Genome Data Viewer
    Location:
    26F3-26F5; 2-21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6649388..6654574)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6649388..6654574)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 26F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transport and golgi organization 1
    Names
    CG11098-PA
    CG11098-PC
    CG11098-PD
    Tango1-PA
    Tango1-PC
    Tango1-PD
    transport and golgi organisation 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6649388..6654574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135214.4NP_609058.2  transport and golgi organization 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609058.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY42, Q9VMA7, Q9VMA8
      Related
      FBpp0078925
      Conserved Domains (5) summary
      pfam06346
      Location:12911337
      Drf_FH1; Formin Homology Region 1
      pfam12474
      Location:496606
      PKK; Polo kinase kinase
      cd16269
      Location:560571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495585
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_001298755.1NP_001285684.1  transport and golgi organization 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J786
      Conserved Domains (5) summary
      COG1196
      Location:4951204
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06346
      Location:12851331
      Drf_FH1; Formin Homology Region 1
      cd16269
      Location:560571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495585
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. NM_164697.3NP_723198.2  transport and golgi organization 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723198.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY42, Q9VMA7, Q9VMA8
      Conserved Domains (5) summary
      pfam06346
      Location:12911337
      Drf_FH1; Formin Homology Region 1
      pfam12474
      Location:496606
      PKK; Polo kinase kinase
      cd16269
      Location:560571
      GBP_C; coiled coil [structural motif]
      cl17036
      Location:42113
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:495585
      GBP_C; Guanylate-binding protein, C-terminal domain