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    COX7A Cytochrome c oxidase subunit 7A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50002, updated on 9-Dec-2024

    Summary

    Official Symbol
    COX7Aprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 7Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040529
    Locus tag
    Dmel_CG9603
    See related
    AllianceGenome:FB:FBgn0040529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9603; COX-7A; cox7a; Cox7a; COX7a; COX7A1; COXJ; COXK; Dmel\CG9603; Q9VHS2; VIIa
    Summary
    Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in adult head and adult heart. Used to study cytochrome-c oxidase deficiency disease and epilepsy. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See COX7A in Genome Data Viewer
    Location:
    84F13-84F13; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8339944..8341043, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4165666..4166765, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pox meso Neighboring gene Odorant receptor 85a Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Cytochrome c oxidase subunit 7A-like

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrion PubMed 
    part_of respiratory chain complex  
    part_of respiratory chain complex IV PubMed 
    part_of respiratory chain complex IV  

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 7A
    Names
    CG9603-PA
    CG9603-PB
    COX7A-PA
    COX7A-PB
    cytochrome c oxidase VIIa
    cytochrome c oxidase polypeptide VIIa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8339944..8341043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143927.4 → NP_652184.2  cytochrome c oxidase subunit 7A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652184.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQX3, Q9VHS2
      Related
      FBpp0081344
      Conserved Domains (1) summary
      cd00928
      Location:31 → 85
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    2. NM_001260057.1 → NP_001246986.1  cytochrome c oxidase subunit 7A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6C3, D1Z3A3
      Conserved Domains (1) summary
      cd00928
      Location:40 → 94
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
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