TFAM mitochondrial transcription factor A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TFAMprovided by FlyBase
Official Full Name: mitochondrial transcription factor Aprovided by FlyBase
Primary source: FLYBASE:FBgn0038805
Locus tag: Dmel_CG4217
See related: AllianceGenome:FB:FBgn0038805
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4217; d-mttfa; D-mtTFA; d-tfam; d-TFAM; Dmel\CG4217; DmtTFA; mttfa; mtTFA; MTTFA; tfam; Tfam
Summary: Predicted to enable mitochondrial promoter sequence-specific DNA binding activity and mitochondrial transcription factor activity. Involved in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92F2-92F2; 3-69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20575245..20577010, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16400967..16402732, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
Title: The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
The present results clearly show the effects of TFAM overexpression on the lifespan of Drosophila under both standard conditions and oxidative stress conditions, and our findings contribute to the understanding of the physiological mechanisms involving TFAM in mitochondria.
Title: Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster.
Lon regulates mitochondrial transcription by stabilizing the mitochondrial TFAMmtDNA ratio via selective degradation of TFAM.
Title: Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM).
Mitochondrial transcription factor A is detected in Drosophila brain throughout the developmental process, as well as in non-proliferating tissues, such as flight muscle and cardia, and is also found in spermatids of imagos.
Title: Spatio-temporal expression of Drosophila mitochondrial transcription factor A during development.
The functions of mtTFA were in relation to mitochondrial biogenesis of Drosophila melanogaster.
Title: Drosophila mitochondrial transcription factor A: characterization of its cDNA and expression pattern during development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitochondrial transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondrial transcription factor A

Names: CG4217-PA; CG4217-PB; TFAM-PA; TFAM-PB; mitochondiral transcription fctor a; mitochondrial transcription factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20575245..20577010 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169906.2 → NP_732527.1 mitochondrial transcription factor A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732527.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BR8

Related

FBpp0083356

Conserved Domains (1) summary

cd01390
Location:78 → 142

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
NM_079691.3 → NP_524415.1 mitochondrial transcription factor A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524415.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VDL2

Related

FBpp0083355

Conserved Domains (1) summary

cd01390
Location:51 → 115

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...