Tip60 Tat interactive protein 60kDa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tip60provided by FlyBase
Official Full Name: Tat interactive protein 60kDaprovided by FlyBase
Primary source: FLYBASE:FBgn0026080
Locus tag: Dmel_CG6121
See related: AllianceGenome:FB:FBgn0026080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6121; CG6121; DmEG0007.7; Dmel/TIP60; Dmel\CG6121; Dmel\TIP60; dmHAG405; dTip60; dTIP60; EG0007.7; EG:EG0007.7; TIP-60; tip60; TIP60
Summary: Enables euchromatin binding activity and histone acetyltransferase activity. Involved in several processes, including DNA repair-dependent chromatin remodeling; negative regulation of neuron apoptotic process; and regulation of terminal button organization. Located in nucleus and polytene chromosome interband. Part of NuA4 histone acetyltransferase complex. Is expressed in NMJ bouton and embryonic/larval neuromuscular junction. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4A6-4B1; 1-7 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4114800..4117487, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4008833..4011520, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control.
Title: Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control.
Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
Title: Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease.
Title: Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease.
Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.
Title: Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.
Tip60 protects against amyloid-beta-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegeneration.
Title: Tip60 protects against amyloid-β-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegeneration.
Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.
Title: Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.
In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster.
Title: In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster.
Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A.
Title: Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A.
heterozygosity for Enhancer of Polycomb [E(Pc)], a component of the Tip60 lysine acetyltransferase complex (also known as KAT5 in humans), significantly increased tumor burden in hop(Tum) animals.
Title: Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity.
Results indicate that Tip60 complex coordinates cell cycle progression and expression of bgcn to help drive GSC daughters toward a differentiation program.
Title: Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables euchromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of terminal button organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tat interactive protein 60kDa

Names: CG6121-PA; CG6121-PB; CG6121-PC; Tat-interactive protein; Tat-interactive protein-60 KDa; Tip60-PA; Tip60-PB; Tip60-PC

NP_001259233.1

EC 2.3.1.48

NP_001259234.1

EC 2.3.1.48

NP_572151.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4114800..4117487 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_131923.4 → NP_572151.1 Tat interactive protein 60kDa, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97425, Q960X4

UniProtKB/TrEMBL

M9PGN1

Related

FBpp0070636

Conserved Domains (5) summary

PHA01732
Location:139 → 196

PHA01732; proline-rich protein

pfam01853
Location:316 → 500

MOZ_SAS; MOZ/SAS family

pfam06346
Location:84 → 157

Drf_FH1; Formin Homology Region 1

pfam11717
Location:23 → 78

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:254 → 533

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_001272304.1 → NP_001259233.1 Tat interactive protein 60kDa, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259233.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH08

Conserved Domains (4) summary

PHA01732
Location:139 → 196

PHA01732; proline-rich protein

pfam06346
Location:84 → 157

Drf_FH1; Formin Homology Region 1

pfam11717
Location:23 → 78

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:254 → 462

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_001272305.1 → NP_001259234.1 Tat interactive protein 60kDa, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259234.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97425, Q960X4

UniProtKB/TrEMBL

M9PGN1

Conserved Domains (5) summary

PHA01732
Location:139 → 196

PHA01732; proline-rich protein

pfam01853
Location:316 → 500

MOZ_SAS; MOZ/SAS family

pfam06346
Location:84 → 157

Drf_FH1; Formin Homology Region 1

pfam11717
Location:23 → 78

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:254 → 533

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate