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    mh maternal haploid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32480, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mhprovided by FlyBase
    Official Full Name
    maternal haploidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267977
    Locus tag
    Dmel_CG9203
    See related
    AllianceGenome:FB:FBgn0267977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9203; Dmel\CG9203; fs(1)1182; fs(1)A1182
    Summary
    Enables metalloendopeptidase activity. Involved in UV protection and mitotic cell cycle. Located in germinal vesicle and male pronucleus. Is expressed in oocyte and testis. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    13C4-13C5; 1-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15472804..15475400, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15366837..15369433, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip128 Neighboring gene ALG14, UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haploid cell cultures of Drosophila melanogaster. Debec A. Nature, 1978 Jul 20. PMID 98714
    2. Testing the Drosophila maternal haploid gene for functional divergence and a role in hybrid incompatibility. Castillo DM, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876798, Free PMC Article
    3. Chimaeras of Drosophila melanogaster obtained by injection of haploid nuclei. Santamaría P, et al. Nature, 1980 Sep 11. PMID 6776407
    4. Analysis of haploid mosaics in Drosophila. Santamaria P. Dev Biol, 1983 Apr. PMID 6832473
    5. Quantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size. Puah WC, et al. Biol Open, 2017 Mar 15. PMID 28108477, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MH is essential for genome integrity during embryogenesis. MH regulates Top2, possibly as a protease for the resolution of Top2-DNA intermediates.
      Title: Maternal Haploid, a Metalloprotease Enriched at the Largest Satellite Repeat and Essential for Genome Integrity in Drosophila Embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UV protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    maternal haploid
    Names
    CG9203-PA
    fs(1)maternal haploid
    mh-PA
    spartan
    NP_573032.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15472804..15475400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132804.2 → NP_573032.1  maternal haploid [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLS7, Q9VXU6
      Related
      FBpp0073890
      Conserved Domains (2) summary
      smart00734
      Location:582 → 605
      ZnF_Rad18; Rad18-like CCHC zinc finger
      pfam10263
      Location:124 → 294
      SprT-like; SprT-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXU6 Q9VXU6

    Gene LinkOut

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