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    GluClalpha Glutamate-gated chloride channel subunit alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42350, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GluClalphaprovided by FlyBase
    Official Full Name
    Glutamate-gated chloride channel subunit alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024963
    Locus tag
    Dmel_CG7535
    See related
    AllianceGenome:FB:FBgn0024963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:HL07853; CG7535; CT23049; dGluCl-alpha; Dm-GluCl; Dmel\CG7535; DmGlu; DmGluClalpha; DrosGlu-Cl-alpha; DrosGluCl; DrosGluCl-alpha; DrosGluCl-alpha1; glc; glu; GluCalpha; GluCl; GLUCL; GluCla; gluClalpha; GluClalpha1
    Summary
    Enables extracellularly glutamate-gated chloride channel activity. Involved in chloride transport. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in adult head; larval central nervous system; optic lobe narrow field columnar neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Orthologous to several human genes including GLRA1 (glycine receptor alpha 1) and GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See GluClalpha in Genome Data Viewer
    Location:
    92B1-92B2; 3-67 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19730715..19775231)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15556437..15600953)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-5 Neighboring gene Nicotinamide amidase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43488 Neighboring gene Acyl-CoA synthetase X1 L Neighboring gene Acyl-CoA synthetase X1 R Neighboring gene Acyl-CoA synthetase X2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. Cully DF, et al. J Biol Chem, 1996 Aug 16. PMID 8702744
    2. Descending neurons coordinate anterior grooming behavior in Drosophila. Guo L, et al. Curr Biol, 2022 Feb 28. PMID 35120659
    3. A biophysical account of multiplication by a single neuron. Groschner LN, et al. Nature, 2022 Mar. PMID 35197635, Free PMC Article
    4. Neural mechanism of spatio-chromatic opponency in the Drosophila amacrine neurons. Li Y, et al. Curr Biol, 2021 Jul 26. PMID 34033749
    5. A novel V263I mutation in the glutamate-gated chloride channel of Plutella xylostella (L.) confers a high level of resistance to abamectin. Sun X, et al. Int J Biol Macromol, 2023 Mar 1. PMID 36706876

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 19744302-19749476 mobile_element_type = transposon:Rt1a{}1390

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellularly glutamate-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glutamate-gated chloride channel subunit alpha
    Names
    CG7535-PE
    CG7535-PF
    CG7535-PH
    CG7535-PI
    CG7535-PJ
    CG7535-PK
    CG7535-PL
    CG7535-PM
    CG7535-PN
    CG7535-PO
    CG7535-PP
    GluClalpha-PE
    GluClalpha-PF
    GluClalpha-PH
    GluClalpha-PI
    GluClalpha-PJ
    GluClalpha-PK
    GluClalpha-PL
    GluClalpha-PM
    GluClalpha-PN
    GluClalpha-PO
    GluClalpha-PP
    glutamate-gated chloride channel
    indefinite
    NP_001287408.1
    • unusual splice
    NP_001287409.1
    • unusual splice
    NP_001287410.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19730715..19775231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170185.3 → NP_001163656.2  Glutamate-gated chloride channel subunit alpha, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163656.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      UniProtKB/TrEMBL
      E1JIQ1
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 439
      LIC; Cation transporter family protein

    2. NM_001300481.1 → NP_001287410.1  Glutamate-gated chloride channel subunit alpha, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      UniProtKB/TrEMBL
      A0A0B4LHB9
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 448
      LIC; Cation transporter family protein

    3. NM_001300479.1 → NP_001287408.1  Glutamate-gated chloride channel subunit alpha, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      UniProtKB/TrEMBL
      A0A0B4LID6
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 455
      LIC; Cation transporter family protein

    4. NM_001038972.4 → NP_001034061.2  Glutamate-gated chloride channel subunit alpha, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034061.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      Conserved Domains (3) summary
      TIGR00860
      Location:3 → 439
      LIC; Cation transporter family protein
      pfam02931
      Location:33 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:251 → 436
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    5. NM_001014641.4 → NP_001014641.2  Glutamate-gated chloride channel subunit alpha, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014641.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 440
      LIC; Cation transporter family protein

    6. NM_142570.4 → NP_650827.3  Glutamate-gated chloride channel subunit alpha, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650827.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 448
      LIC; Cation transporter family protein

    7. NM_169873.4 → NP_732447.2  Glutamate-gated chloride channel subunit alpha, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732447.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 448
      LIC; Cation transporter family protein

    8. NM_001300480.1 → NP_001287409.1  Glutamate-gated chloride channel subunit alpha, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      UniProtKB/TrEMBL
      A0A0B4LHB7
      Conserved Domains (3) summary
      TIGR00860
      Location:3 → 447
      LIC; Cation transporter family protein
      pfam02931
      Location:33 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:251 → 444
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    9. NM_001275811.2 → NP_001262740.1  Glutamate-gated chloride channel subunit alpha, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262740.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77295, Q0Q0M3, Q2PDQ5, Q59DV9, Q8IN68, Q94900, Q9GQ52, Q9GQ53, Q9VDU5
      UniProtKB/TrEMBL
      A0A0B4KHS0
      Conserved Domains (1) summary
      TIGR00860
      Location:3 → 449
      LIC; Cation transporter family protein

    10. NM_001170184.2 → NP_001163655.1  Glutamate-gated chloride channel subunit alpha, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIQ2
      Conserved Domains (2) summary
      pfam02931
      Location:33 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:251 → 339
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    11. NM_001170183.2 → NP_001163654.1  Glutamate-gated chloride channel subunit alpha, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGX3
      Conserved Domains (1) summary
      cl27321
      Location:3 → 261
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHS0 A0A0B4KHS0
    A0A0B4LHB7 A0A0B4LHB7
    A0A0B4LHB9 A0A0B4LHB9
    A0A0B4LID6 A0A0B4LID6
    E1JIQ1 E1JIQ1
    E1JIQ2 E1JIQ2
    Q0IGX3 Q0IGX3
    Q94900.2 Q94900

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