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    Pkc53E Protein C kinase 53E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48311, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pkc53Eprovided by FlyBase
    Official Full Name
    Protein C kinase 53Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003091
    Locus tag
    Dmel_CG6622
    See related
    AllianceGenome:FB:FBgn0003091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6622; Dmel\CG6622; dPKC; DPKC; Dpkc1; dPKC53E(br); pck53E; PK-C; PKC; PKC 53B; PKC 53E; PKC-53B; PKC-53E; Pkc1; PKC1; pkc53e; pkc53E; PKC53e; PKC53E
    Summary
    Enables protein serine/threonine kinase activity. Involved in positive regulation of clathrin-dependent endocytosis and regulation of hemocyte proliferation. Predicted to be located in plasma membrane. Is expressed in adult brain; adult head; adult mushroom body; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to several human genes including PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pkc53E in Genome Data Viewer
    Location:
    53E2-53E2; 2-81 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16924655..16945126)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12812160..12832631)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-990 stem loop Neighboring gene inactivation no afterpotential C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. Rosenthal A, et al. EMBO J, 1987 Feb. PMID 3107983, Free PMC Article
    2. The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors. Hoyos B, et al. J Exp Med, 2000 Sep 18. PMID 10993914, Free PMC Article
    3. Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. Smith DP, et al. Science, 1991 Dec 6. PMID 1962207
    4. Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Schaeffer E, et al. Cell, 1989 May 5. PMID 2720775
    5. PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila. Colomb J, et al. PeerJ, 2016. PMID 27168980, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors.
      Title: A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of clathrin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein C kinase 53E
    Names
    CG6622-PA
    CG6622-PB
    CG6622-PC
    CG6622-PD
    CG6622-PE
    CG6622-PF
    Pkc53E-PA
    Pkc53E-PB
    Pkc53E-PC
    Pkc53E-PD
    Pkc53E-PE
    Pkc53E-PF
    protein kinase C
    protein kinase-C 53E
    protein kinase-c1
    NP_001097350.1
    NP_001246377.1
    NP_001246378.1
    NP_001261035.1
    NP_476682.1
    NP_725626.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16924655..16945126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274106.1 → NP_001261035.1  protein C kinase 53E, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT3
      Conserved Domains (4) summary
      cd04026
      Location:168 → 298
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:344 → 663
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      cd20833
      Location:44 → 101
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:111 → 164
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

    2. NM_166201.3 → NP_725626.1  protein C kinase 53E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05130, Q9V7V6, Q9V7V7
      Related
      FBpp0086197
      Conserved Domains (4) summary
      cd04026
      Location:177 → 307
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:353 → 672
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      cd20833
      Location:44 → 110
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:120 → 173
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

    3. NM_001103880.3 → NP_001097350.1  protein C kinase 53E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYG9
      Conserved Domains (4) summary
      cd04026
      Location:176 → 306
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:349 → 607
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:352 → 671
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:119 → 171
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. NM_001259449.1 → NP_001246378.1  protein C kinase 53E, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYG9
      Conserved Domains (4) summary
      cd04026
      Location:176 → 306
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:349 → 607
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05587
      Location:352 → 671
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:119 → 171
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. NM_057334.3 → NP_476682.1  protein C kinase 53E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT3
      Related
      FBpp0086198
      Conserved Domains (4) summary
      cd04026
      Location:168 → 298
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:344 → 663
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      cd20833
      Location:44 → 101
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:111 → 164
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

    6. NM_001259448.1 → NP_001246377.1  protein C kinase 53E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK5
      Conserved Domains (2) summary
      cd04026
      Location:23 → 153
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:199 → 518
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFT3 A0A0B4KFT3
    A8DYG9 A8DYG9
    D3DMK5 D3DMK5
    P05130.2 P05130

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