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    Srrm234 Serine-arginine repetitive matrix 2/3/4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srrm234provided by FlyBase
    Official Full Name
    Serine-arginine repetitive matrix 2/3/4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035253
    Locus tag
    Dmel_CG7971
    See related
    AllianceGenome:FB:FBgn0035253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1A7; BcDNA:GH04236; CG7971; Dmel\CG7971; SRm300
    Summary
    Involved in alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srrm234 in Genome Data Viewer
    Location:
    62A10-62A10; 3-0.5 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1654247..1665064, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1654247..1665064, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45815 Neighboring gene uncharacterized protein Neighboring gene Vesicle trafficking 1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L23A Neighboring gene U snoRNA host gene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals. Torres-Méndez A, et al. Sci Adv, 2022 Jan 28. PMID 35089784, Free PMC Article
    2. A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons. Torres-Méndez A, et al. Nat Ecol Evol, 2019 Apr. PMID 30833759
    3. Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles. Lacroix E, et al. Front Mol Biosci, 2022. PMID 36203874, Free PMC Article
    4. Srrm234, but not canonical SR and hnRNP proteins, drive inclusion of Dscam exon 9 variable exons. Ustaoglu P, et al. RNA, 2019 Oct. PMID 31292260, Free PMC Article
    5. Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons. Petruccelli E, et al. Genetics, 2020 May. PMID 32132098, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Serine-arginine repetitive matrix 2/3/4
    Names
    CG7971-PA
    CG7971-PB
    CG7971-PC
    CG7971-PF
    CG7971-PG
    CG7971-PH
    CG7971-PI
    CG7971-PJ
    CG7971-PK
    CG7971-PL
    Srrm234-PA
    Srrm234-PB
    Srrm234-PC
    Srrm234-PF
    Srrm234-PG
    Srrm234-PH
    Srrm234-PI
    Srrm234-PJ
    Srrm234-PK
    Srrm234-PL
    anon-fast-evolving-1A7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1654247..1665064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167909.4 → NP_728652.1  Serine-arginine repetitive matrix 2/3/4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960C4, Q9W0B0, Q9W0B1
      Related
      FBpp0072689
      Conserved Domains (2) summary
      pfam08312
      Location:58 → 98
      cwf21; cwf21 domain
      pfam15230
      Location:1036 → 1062
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus

    2. NM_001414146.1 → NP_001401026.1  Serine-arginine repetitive matrix 2/3/4, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0X7, Q960C4

    3. NM_001259619.2 → NP_001246548.1  Serine-arginine repetitive matrix 2/3/4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ99, Q960C4
      Conserved Domains (1) summary
      pfam08312
      Location:58 → 98
      cwf21; cwf21 domain

    4. NM_001414147.1 → NP_001401027.1  Serine-arginine repetitive matrix 2/3/4, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0X8, Q960C4

    5. NM_001104005.3 → NP_001097475.2  Serine-arginine repetitive matrix 2/3/4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097475.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNI2
      Conserved Domains (3) summary
      pfam08312
      Location:58 → 98
      cwf21; cwf21 domain
      pfam10243
      Location:672 → 936
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam15230
      Location:1584 → 1610
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus

    6. NM_139385.4 → NP_647642.2  Serine-arginine repetitive matrix 2/3/4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ99, Q960C4
      Related
      FBpp0072688
      Conserved Domains (1) summary
      pfam08312
      Location:58 → 98
      cwf21; cwf21 domain

    7. NM_001414144.1 → NP_001400988.1  Serine-arginine repetitive matrix 2/3/4, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2GM10, Q960C4

    8. NM_001414145.1 → NP_001401025.1  Serine-arginine repetitive matrix 2/3/4, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0X6

    9. NM_001299974.1 → NP_001286903.1  Serine-arginine repetitive matrix 2/3/4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8K5

    10. NM_167910.3 → NP_728653.2  Serine-arginine repetitive matrix 2/3/4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728653.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BP9, Q86NV4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A9F2GM10 A0A9F2GM10
    A8JNI2 A8JNI2
    Q7YZ99 Q7YZ99
    Q86BP9 Q86BP9
    Q95TP3 Q95TP3
    Q960C4 Q960C4
    Q9W0B0 Q9W0B0
    X2J8K5 X2J8K5

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