aub aubergine [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aubprovided by FlyBase
Official Full Name: aubergineprovided by FlyBase
Primary source: FLYBASE:FBgn0000146
Locus tag: Dmel_CG6137
See related: AllianceGenome:FB:FBgn0000146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aub; AUB; AUBERGINE; CG6137; Dmel\CG6137; ms(2)32D; sti; sting
Summary: Enables RNA endonuclease activity, producing 5'-phosphomonoesters; mRNA binding activity; and piRNA binding activity. Involved in several processes, including dorsal appendage formation; negative regulation of gene expression; and oocyte development. Located in P granule. Is expressed in adult head; female germline cyst; germarium; germline cell; and gonad. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1); PIWIL3 (piwi like RNA-mediated gene silencing 3); and PIWIL4 (piwi like RNA-mediated gene silencing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32C1-32C1; 2-44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10997819..11001476, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10997819..11001476, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster.
Title: Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster.
Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation.
Title: Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation.
Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.
Title: Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.
The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm.
Title: The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm.
Caz is a Drosophila homologue of FUS, which is one of the genes causing amyotrophic lateral sclerosis (ALS). The novel roles for Caz and Aub demonstrated herein using the Caz-knockdown fly will contribute to a deeper understanding of the pathogenesis of ALS.
Title: Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders.
We propose that Armi shuttles between nuage and mitochondria, feeding precursor piRNAs generated by Ago3 cleavage into the Zucchini-dependent production of Aubergine- and Piwi-bound piRNAs on the mitochondrial surface.
Title: The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria.
The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and transposable elements silencing.
Title: The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and TE silencing.
STING participated in the control of infection by picorna-like viruses, acting upstream of IKKb to regulate expression of Nazo, an antiviral factor.
Title: The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.
piRNAs and Aub actively protect germ cell mRNAs in the germ plasm. Aub directly interacts with the germline-specific poly(A) polymerase Wispy, thus leading to mRNA polyadenylation and stabilization in the germ plasm.
Title: piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.
Eyg interacts with Aubergine (Aub), a component of the pi-RNA pathway during egg chamber development. This interaction could be essential for Eyg to be retained in the cytoplasm and fulfill its functions there.
Title: The Pax protein Eyegone (Eyg) interacts with the pi-RNA component Aubergine (Aub) and controls egg chamber development in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA endonuclease activity, producing 5'-phosphomonoesters	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	EXP Inferred from Experiment more info	PubMed
enables piRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables piRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables piRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in dorsal appendage formation	HMP more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in global gene silencing by mRNA cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of pole plasm mRNA location	TAS Traceable Author Statement more info	PubMed
involved_in maternal mRNA clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte karyosome formation	TAS Traceable Author Statement more info	PubMed
involved_in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	HMP more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in piRNA-mediated gene silencing by mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translational initiation	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in positive regulation of oskar mRNA translation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of oskar mRNA translation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by mRNA destabilization	IC Inferred by Curator more info	PubMed
involved_in transposable element silencing by piRNA-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aubergine

Names: Aub; CG6137-PA; CG6137-PC; aub-PA; aub-PC; stellate-interacting gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10997819..11001476 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057386.5 → NP_476734.1 aubergine, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8DYZ0, K7WQ34, K7X543, K7XHY9, L0CPY1, L0CQ70, L0CRA0, L0CRA6, L0CRP1, L0CRZ4, L0CS00, O76922

Related

FBpp0079754

Conserved Domains (3) summary

cd02845
Location:272 → 392

PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...

cd04658
Location:400 → 849

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam16486
Location:105 → 219

ArgoN; N-terminal domain of argonaute
NM_001103674.3 → NP_001097144.1 aubergine, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097144.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76922

Conserved Domains (3) summary

cd02845
Location:201 → 321

PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...

cd04658
Location:329 → 778

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam16486
Location:34 → 148

ArgoN; N-terminal domain of argonaute