Nlg2 Neuroligin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nlg2provided by FlyBase
Official Full Name: Neuroligin 2provided by FlyBase
Primary source: FLYBASE:FBgn0031866
Locus tag: Dmel_CG13772
See related: AllianceGenome:FB:FBgn0031866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13772; Dmel\CG13772; dnl2; dnlg2; Dnlg2; DNlg2; neuroligin; Neuroligin; nl2; Nlg-2; nlg2
Summary: Enables neurexin family protein binding activity. Involved in several processes, including adult walking behavior; inter-male aggressive behavior; and synapse organization. Located in neuromuscular junction and postsynaptic membrane. Is expressed in several structures, including adult head; embryonic/larval neuromuscular junction; ganglia; larval central nervous system; and larval nervous system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN1 (neuroligin 1); NLGN2 (neuroligin 2); and NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27C1-27C4; 2-23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6874900..6906656)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6874900..6906656)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila.
Title: Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila.
Neuroligin 2 undergoes proteolytic cleavage in the endoplasmic reticulum in a variety of Drosophila tissues throughout developmental stages.
Title: Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila.
Although dnl2 is not absolutely required for synaptogenesis, it is required postsynaptically for synapse maturation and function.[neuroligin 2]
Title: Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction.
miR-932 downregulated expression of dnlg2 in S2 cell, and the repression of dnlg2 by miR-932 at both protein and RNA level.
Title: Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2.
This study demonistrated that Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour
Title: Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour.
drosophila nlg2 functions both presynaptically and postsynaptically together with Neurexin to determine the proper number of boutons as well as the number of active zones and size of synaptic densities during the development of neuromuscular junctions.
Title: Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.
Several mutant alleles of neuroligin 1 are discovered that cause a severe reduction in bouton numbers at neuromuscular junctions.
Title: Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 6876832-6882964 mobile_element_type = transposon:diver{}317

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of presynaptic active zone structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing generated song production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info