Miga Mitoguardin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Migaprovided by FlyBase
Official Full Name: Mitoguardinprovided by FlyBase
Primary source: FLYBASE:FBgn0030037
Locus tag: Dmel_CG12125
See related: AllianceGenome:FB:FBgn0030037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12125; Dmel\CG12125; miga
Summary: Enables phosphatidylinositol 3-kinase activator activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of mitophagy; and regulation of mitochondrial fusion. Located in mitochondrion. Is active in mitochondrial outer membrane. Is expressed in adult head. Orthologous to several human genes including MIGA2 (mitoguardin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8433923..8437820, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8327956..8331853, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Miga-mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis.
Title: Miga-mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain