Klf15 Kruppel-like factor 15 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Klf15provided by FlyBase
Official Full Name: Kruppel-like factor 15provided by FlyBase
Primary source: FLYBASE:FBgn0025679
Locus tag: Dmel_CG2932
See related: AllianceGenome:FB:FBgn0025679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: *z FBgn0; Bteb2; BteB2; BTEB2; CG2932; dKlf15; dKLF15; Dmel\CG2932; KLF
Summary: Enables sequence-specific DNA binding activity. Involved in nephrocyte diaphragm assembly; nephrocyte differentiation; and response to silver ion. Predicted to be located in nucleus. Is expressed in adult pericardial cell; embryonic/larval garland cell; garland cell primordium; larval pericardial cell; and organism. Used to study cardiomyopathy. Orthologous to human KLF15 (KLF transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4770557..4771588, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4664590..4665621, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in garland nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephrocyte diaphragm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to silver ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain