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    TwdlL TweedleL [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlLprovided by FlyBase
    Official Full Name
    TweedleLprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039437
    Locus tag
    Dmel_CG6447
    See related
    AllianceGenome:FB:FBgn0039437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6447; Dmel\CG6447; TwdIL
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlL in Genome Data Viewer
    Location:
    97C2-97C2; 3-91 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26624587..26625652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22450309..22451374, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleP Neighboring gene TweedleB Neighboring gene TweedleO Neighboring gene TweedleK

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
    2. Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies. Stern S, et al. J Physiol, 2014 Jun 1. PMID 24535443, Free PMC Article
    3. The distribution of GYR- and YLP-like motifs in Drosophila suggests a general role in cuticle assembly and other protein-protein interactions. Cornman RS. PLoS One, 2010 Sep 2. PMID 20824096, Free PMC Article
    4. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article
    5. Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle. Cornman RS, et al. Insect Mol Biol, 2009 Oct. PMID 19754739, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleL
    Names
    CG6447-PA
    CG6447-PB
    TwdlL-PA
    TwdlL-PB
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26624587..26625652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170279.3 → NP_733158.1  TweedleL, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXS1, Q9VBD9
      Related
      FBpp0084428
      Conserved Domains (1) summary
      smart00690
      Location:122 → 223
      DM5; Domain of unknown function, currently peculiar to Drosophila

    2. NM_170280.2 → NP_733159.1  TweedleL, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0N3, Q8SXS1
      Related
      FBpp0084427
      Conserved Domains (1) summary
      smart00690
      Location:116 → 217
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I0N3 Q8I0N3
    Q9VBD9 Q9VBD9

    Gene LinkOut

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