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    YL-1 YL-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YL-1provided by FlyBase
    Official Full Name
    YL-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032321
    Locus tag
    Dmel_CG4621
    See related
    AllianceGenome:FB:FBgn0032321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4621; Dmel\CG4621; dYL-1; dYL1; YL1
    Summary
    Predicted to enable ATP-dependent H2AZ histone chaperone activity. Involved in DNA repair-dependent chromatin remodeling and negative regulation of gene expression. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Is expressed in organism. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See YL-1 in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10970443..10972093)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10970443..10972093)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 2 Neighboring gene long non-coding RNA:CR44493 Neighboring gene Transmembrane protein 214 Neighboring gene uncharacterized protein Neighboring gene abnormal oocyte

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Liang X, et al. Nat Struct Mol Biol, 2016 Apr. PMID 26974124
    2. Nucleosomes are context-specific, H2A.Z-modulated barriers to RNA polymerase. Weber CM, et al. Mol Cell, 2014 Mar 6. PMID 24606920
    3. Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster. Prozzillo Y, et al. Cells, 2023 May 9. PMID 37408183, Free PMC Article
    4. In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster. Prozzillo Y, et al. Int J Mol Sci, 2021 Apr 26. PMID 33926075, Free PMC Article
    5. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    YL-1
    Names
    CG4621-PA
    CG4621-PB
    YL-1-PA
    YL-1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10970443..10972093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298894.1 → NP_001285823.1  YL-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKM6
      UniProtKB/TrEMBL
      X2JA36
      Conserved Domains (3) summary
      smart00993
      Location:276 → 304
      YL1_C; YL1 nuclear protein C-terminal domain
      pfam04180
      Location:20 → 75
      LTV; Low temperature viability protein
      pfam05764
      Location:3 → 218
      YL1; YL1 nuclear protein

    2. NM_135631.4 → NP_609475.1  YL-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKM6
      UniProtKB/TrEMBL
      X2JA36
      Related
      FBpp0079735
      Conserved Domains (3) summary
      smart00993
      Location:276 → 304
      YL1_C; YL1 nuclear protein C-terminal domain
      pfam04180
      Location:20 → 75
      LTV; Low temperature viability protein
      pfam05764
      Location:3 → 218
      YL1; YL1 nuclear protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKM6.1 Q9VKM6
    X2JA36 X2JA36

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