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    Smox Smad on X [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31738, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Smoxprovided by FlyBase
    Official Full Name
    Smad on Xprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025800
    Locus tag
    Dmel_CG2262
    See related
    AllianceGenome:FB:FBgn0025800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp
    Summary
    Enables chromatin DNA binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; imaginal disc-derived wing morphogenesis; and nervous system development. Located in cytosol and nucleus. Part of heteromeric SMAD protein complex. Is expressed in several structures, including embryonic anal pad; embryonic/larval midgut; ganglia; germline cell; and larval muscle cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome (multiple); Lynch syndrome; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smox in Genome Data Viewer
    Location:
    7D14-7D15; 1-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8137041..8142279, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8031074..8036312, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cypher Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, alpha-subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Smad2 degradation occurs independently of linker phosphorylations. Castro K, et al. MicroPubl Biol, 2024. PMID 38601902, Free PMC Article
    2. Conservation and evolutionary divergence in the activity of receptor-regulated smads. Sorrentino GM, et al. Evodevo, 2012 Oct 1. PMID 23020873, Free PMC Article
    3. Reducing the Excess Activin Signaling Rescues Muscle Degeneration in Myotonic Dystrophy Type 2 Drosophila Model. Deng J, et al. J Pers Med, 2022 Mar 2. PMID 35330385, Free PMC Article
    4. A Drosophila model of early onset torsion dystonia suggests impairment in TGF-beta signaling. Koh YH, et al. Hum Mol Genet, 2004 Sep 15. PMID 15269177
    5. Developmental arrest of Drosophila larvae elicits presynaptic depression and enables prolonged studies of neurodegeneration. Perry S, et al. Development, 2020 May 21. PMID 32345746, Free PMC Article

    See all (185) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females.
      Title: dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females.
    2. Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
      Title: Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
    3. Tissue-autonomous loss of Smad2 leads to wide wing discs.
      Title: Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.
    4. Reduction of the Medea or Smox, corrected both heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
      Title: SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
    5. Smox acts downstream of Sax to prevent spermatogonial over-proliferation in Drosophila.
      Title: TGFbeta receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables co-SMAD binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_positive_effect determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heteromeric SMAD protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    smad on X
    Names
    CG2262-PA
    CG2262-PB
    Smox-PA
    Smox-PB
    Smox/dSmad2
    sisters against dpp
    temporarily deranged

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8137041..8142279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298077.1 → NP_001285006.1  smad on X, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96660, Q9TZQ2
      Conserved Domains (2) summary
      cd10488
      Location:7 → 130
      MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs
      cd10985
      Location:285 → 475
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. NM_078524.4 → NP_511079.1  smad on X, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96660, Q9TZQ2
      Related
      FBpp0071140
      Conserved Domains (2) summary
      cd10488
      Location:7 → 130
      MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs
      cd10985
      Location:285 → 475
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96660 O96660
    Q86NL2 Q86NL2
    Q9TZQ2 Q9TZQ2

    Gene LinkOut

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