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    Pgant7 Polypeptide N-Acetylgalactosaminyltransferase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant7provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0030930
    Locus tag
    Dmel_CG6394
    See related
    AllianceGenome:FB:FBgn0030930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02059370.15; CG6394; dGalNAc-T2; Dmel\CG6394; GalNAc-T2; pgant7; PGANT7
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult head; dorsal ectoderm; embryonic/larval midgut primordium; gut section; and imaginal disc. Orthologous to human GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant7 in Genome Data Viewer
    Location:
    17B6-17B6; 1-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18495067..18499986, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18389100..18394019, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45627 Neighboring gene X-ray repair cross complementing 2 Neighboring gene Wnt oncogene analog 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Bennett EP, et al. Glycoconj J, 2010 May. PMID 20422447
    2. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. Xie L, et al. BMC Genomics, 2013. PMID 23819581, Free PMC Article
    3. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    4. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    5. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 7
    Names
    CG6394-PA
    CG6394-PB
    CG6394-PC
    Pgant7-PA
    Pgant7-PB
    Pgant7-PC
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
    polypeptide GalNAc transferase 7
    NP_001285406.1
    NP_573301.2
    NP_728178.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18495067..18499986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298477.1 → NP_001285406.1  polypeptide N-Acetylgalactosaminyltransferase 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4R2, Q5U0W9, Q8MV48, Q95RJ3, Q95TN2, Q9VWT6
      UniProtKB/TrEMBL
      X2JEA3
      Conserved Domains (4) summary
      cd02510
      Location:145 → 452
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:469 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:468 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:142 → 373
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    2. NM_167623.2 → NP_728178.1  polypeptide N-Acetylgalactosaminyltransferase 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4R2, Q5U0W9, Q8MV48, Q95RJ3, Q95TN2, Q9VWT6
      UniProtKB/TrEMBL
      X2JEA3
      Related
      FBpp0074396
      Conserved Domains (4) summary
      cd02510
      Location:145 → 452
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:469 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:468 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:142 → 373
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    3. NM_133073.3 → NP_573301.2  polypeptide N-Acetylgalactosaminyltransferase 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573301.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4R2, Q5U0W9, Q8MV48, Q95RJ3, Q95TN2, Q9VWT6
      UniProtKB/TrEMBL
      X2JEA3
      Related
      FBpp0074395
      Conserved Domains (4) summary
      cd02510
      Location:145 → 452
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:469 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:468 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:142 → 373
      Glyco_tranf_2_3; Glycosyltransferase like family 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MV48.2 Q8MV48
    X2JEA3 X2JEA3

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