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    CG32264 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32264provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052264
    Locus tag
    Dmel_CG32264
    See related
    AllianceGenome:FB:FBgn0052264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10857; CG10860; CG12604; CG14978; Dmel\CG32264
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytosol and nucleus. Is expressed in adult brain; anterior midgut primordium; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Parkinson's disease; artery disease (multiple); brain disease (multiple); and multiple sclerosis. Orthologous to several human genes including PHACTR1 (phosphatase and actin regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32264 in Genome Data Viewer
    Location:
    63E8-63F1; 3-9 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3714826..3806459, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3714826..3806459, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45675 Neighboring gene uncharacterized protein Neighboring gene pickpocket 27 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Integrator 10 Neighboring gene nutcracker

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytological heterogeneity of heterochromatin among 10 sequenced Drosophila species. Marchetti M, et al. Genetics, 2022 Sep 30. PMID 35946576, Free PMC Article
    2. Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Brody T, et al. Dev Dyn, 2012 Jan. PMID 22174086, Free PMC Article
    3. Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. Dobson AJ, et al. Nat Commun, 2015 Feb 18. PMID 25692519, Free PMC Article
    4. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Guzman RM, et al. Genetics, 2021 Mar 31. PMID 33789347, Free PMC Article
    5. Female Genetic Contributions to Sperm Competition in Drosophila melanogaster. Chen DS, et al. Genetics, 2019 Jul. PMID 31101677, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32264-PB
    CG32264-PD
    CG32264-PE
    CG32264-PG
    CG32264-PI
    CG32264-PJ
    CG32264-PK
    CG32264-PL
    CG32264-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3714826..3806459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206268.4 → NP_995990.3  uncharacterized protein Dmel_CG32264, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995990.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R7R0
      Conserved Domains (2) summary
      smart00707
      Location:703 → 728
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:149 → 171
      RPEL; RPEL repeat

    2. NM_001104025.2 → NP_001097495.2  uncharacterized protein Dmel_CG32264, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097495.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNJ8
      Conserved Domains (2) summary
      smart00707
      Location:808 → 833
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:254 → 276
      RPEL; RPEL repeat

    3. NM_168037.2 → NP_728896.1  uncharacterized protein Dmel_CG32264, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZM9
      Related
      FBpp0300860
      Conserved Domains (2) summary
      smart00707
      Location:818 → 843
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:254 → 276
      RPEL; RPEL repeat

    4. NM_001274446.1 → NP_001261375.1  uncharacterized protein Dmel_CG32264, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE70
      Conserved Domains (2) summary
      smart00707
      Location:640 → 665
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:86 → 108
      RPEL; RPEL repeat

    5. NM_001104024.2 → NP_001097494.1  uncharacterized protein Dmel_CG32264, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU16
      Conserved Domains (2) summary
      smart00707
      Location:879 → 904
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:325 → 347
      RPEL; RPEL repeat

    6. NM_168038.2 → NP_728897.1  uncharacterized protein Dmel_CG32264, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZN0
      Related
      FBpp0073043
      Conserved Domains (2) summary
      smart00707
      Location:889 → 914
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:325 → 347
      RPEL; RPEL repeat

    7. NM_001259678.1 → NP_001246607.1  uncharacterized protein Dmel_CG32264, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7A5
      Conserved Domains (1) summary
      smart00707
      Location:390 → 415
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    8. NM_001202114.1 → NP_001189043.1  uncharacterized protein Dmel_CG32264, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRV3
      Conserved Domains (1) summary
      smart00707
      Location:345 → 370
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    9. NM_168039.3 → NP_728898.1  uncharacterized protein Dmel_CG32264, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZJ7, Q9VZN2
      Related
      FBpp0073044
      Conserved Domains (1) summary
      smart00707
      Location:671 → 696
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNJ8 A8JNJ8
    D4G7A5 D4G7A5
    E0R7R0 E0R7R0
    M9MRV3 M9MRV3
    M9PE70 M9PE70
    Q7YU16 Q7YU16
    Q8IH02 Q8IH02
    Q9VZM9 Q9VZM9
    Q9VZN0 Q9VZN0
    Q9VZN2 Q9VZN2

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