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    Slmap Sarcolemma associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slmapprovided by FlyBase
    Official Full Name
    Sarcolemma associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040011
    Locus tag
    Dmel_CG17494
    See related
    AllianceGenome:FB:FBgn0040011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17494; Dmel\CG17494; slmap; SLMAP
    Summary
    Enables protein kinase binding activity. Involved in negative regulation of hippo signaling and negative regulation of peptidoglycan recognition protein signaling pathway. Part of FAR/SIN/STRIPAK complex. Is expressed in adult head and organism. Orthologous to several human genes including SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slmap in Genome Data Viewer
    Location:
    40F7-40F7; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22579072..22585843)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22471804..22478575)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43927 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster. Mao B, et al. Insect Sci, 2022 Dec. PMID 35271765
    2. STRIPAK complexes: structure, biological function, and involvement in human diseases. Hwang J, et al. Int J Biochem Cell Biol, 2014 Feb. PMID 24333164, Free PMC Article
    3. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Zheng Y, et al. Cell Rep, 2017 Dec 19. PMID 29262338, Free PMC Article
    4. The SILAC fly allows for accurate protein quantification in vivo. Sury MD, et al. Mol Cell Proteomics, 2010 Oct. PMID 20525996, Free PMC Article
    5. A conserved STRIPAK complex is required for autophagy in muscle tissue. Guo Y, et al. Mol Biol Cell, 2023 Aug 1. PMID 37379167, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction HGI PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sarcolemma associated protein
    Names
    CG17494-PA
    CG17494-PD
    Slmap-PA
    Slmap-PD
    sarcolemma associated protein ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22579072..22585843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042934.2 → NP_001036399.1  sarcolemma associated protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH6, Q0E8L9, Q9W5R5
      Conserved Domains (2) summary
      COG1716
      Location:225 → 326
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:216 → 311
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    2. NM_001042932.2 → NP_001036397.2  sarcolemma associated protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036397.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH6, Q0E8L9, Q9W5R5
      Conserved Domains (2) summary
      COG1716
      Location:225 → 326
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:216 → 311
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5R5 Q9W5R5

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