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    Paf-AHalpha Platelet-activating factor acetylhydrolase alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paf-AHalphaprovided by FlyBase
    Official Full Name
    Platelet-activating factor acetylhydrolase alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025809
    Locus tag
    Dmel_CG8962
    See related
    AllianceGenome:FB:FBgn0025809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAC83820; CG8962; Dmaalpha[[PAFAH]]; Dmel\CG8962; Paf-Aha; PAFAHalpha
    Summary
    Is expressed in adult abdomen; adult head; adult thorax; organism; and ovary. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2) and PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Paf-AHalpha in Genome Data Viewer
    Location:
    13E18-13E18; 1-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15784009..15785583, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15678042..15679616, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene EF-hand domain containing 1.1 Neighboring gene mitochondrial ribosomal protein S30 Neighboring gene Rhophilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome. Sheffield PJ, et al. Proteins, 2000 Apr 1. PMID 10737922
    2. Nuclear migration. From fungi to the mammalian brain. Morris NR. J Cell Biol, 2000 Mar 20. PMID 10725321, Free PMC Article
    3. Identification of ALK in Thinness. Orthofer M, et al. Cell, 2020 Jun 11. PMID 32442405
    4. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article
    5. Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster. Yu KE, et al. Mol Cells, 2018 Feb 28. PMID 29429152, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Platelet-activating factor acetylhydrolase alpha
    Names
    CG8962-PA
    CG8962-PB
    Paf-AHalpha-PA
    Paf-AHalpha-PB
    platelet-activating factor acetylhydrolase Ib alpha-subunit homolog
    platelet-activating factor acetylhydrolase alpha subunit homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15784009..15785583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080350.4 → NP_525089.2  Platelet-activating factor acetylhydrolase alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525089.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4G6, O96644, Q9VXP4
      Related
      FBpp0073976
      Conserved Domains (1) summary
      cd01820
      Location:3 → 212
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    2. NM_167461.2 → NP_727895.1  Platelet-activating factor acetylhydrolase alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4G6, O96644, Q9VXP4
      Related
      FBpp0073975
      Conserved Domains (1) summary
      cd01820
      Location:3 → 212
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXP4.1 Q9VXP4

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