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    Grip75 Grip75 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grip75provided by FlyBase
    Official Full Name
    Grip75provided by FlyBase
    Primary source
    FLYBASE:FBgn0026431
    Locus tag
    Dmel_CG6176
    See related
    AllianceGenome:FB:FBgn0026431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    75p; CG6176; d75p; dGrip75; Dgrip75; DGrip75; Dgrip75/d75p; Dgrip75s; Dmel\CG6176; grip75
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in several processes, including bicoid mRNA localization; meiotic nuclear division; and mitotic spindle-templated microtubule nucleation. Part of gamma-tubulin ring complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 3. Orthologous to human TUBGCP4 (tubulin gamma complex component 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grip75 in Genome Data Viewer
    Location:
    31F1-31F1; 2-43 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10483295..10485857)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10483295..10485857)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RluA pseudouridine synthase 1 Neighboring gene RluA pseudouridine synthase 2 Neighboring gene Component of oligomeric golgi complex 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Myosin 31DF Neighboring gene antisense RNA:CR44224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human 76p: A new member of the gamma-tubulin-associated protein family. Fava F, et al. J Cell Biol, 1999 Nov 15. PMID 10562286, Free PMC Article
    2. Comparative Expression Profiling of Wild Type Drosophila Malpighian Tubules and von Hippel-Lindau Haploinsufficient Mutant. Ignesti M, et al. Front Physiol, 2019. PMID 31191337, Free PMC Article
    3. Loss of Pseudouridine Synthases in the RluA Family Causes Hypersensitive Nociception in Drosophila. Song W, et al. G3 (Bethesda), 2020 Dec 3. PMID 33028630, Free PMC Article
    4. {gamma}-Tubulin ring complexes regulate microtubule plus end dynamics. Bouissou A, et al. J Cell Biol, 2009 Nov 2. PMID 19948476, Free PMC Article
    5. Golgi Outposts Locally Regulate Microtubule Orientation in Neurons but Are Not Required for the Overall Polarity of the Dendritic Cytoskeleton. Yang SZ, et al. Genetics, 2020 Jun. PMID 32265236, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis
      Title: Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis.
    2. Function of this specific subunit of the ring complex was determined.
      Title: Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bicoid mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly involved in female meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin ring complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Grip75
    Names
    CG6176-PA
    DGrip75
    Grip75-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10483295..10485857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135568.4 → NP_609412.1  Grip75 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1J7, Q9VKU7
      UniProtKB/TrEMBL
      T1W1Y2
      Related
      FBpp0079623
      Conserved Domains (1) summary
      pfam04130
      Location:25 → 548
      Spc97_Spc98; Spc97 / Spc98 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKU7.2 Q9VKU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools