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    CG12398 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12398provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030596
    Locus tag
    Dmel_CG12398
    See related
    AllianceGenome:FB:FBgn0030596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dm GMCgamma1; Dmel\CG12398
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Located in egg chorion. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12398 in Genome Data Viewer
    Location:
    13A1-13A1; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14911781..14913812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14805814..14807845, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene fezzik Neighboring gene uncharacterized protein Neighboring gene Ecdysone oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi H, et al. Biochem J, 2005 Aug 1. PMID 15813704, Free PMC Article
    2. Expansion and evolution of insect GMC oxidoreductases. Iida K, et al. BMC Evol Biol, 2007 May 11. PMID 17498303, Free PMC Article
    3. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article
    4. Minor proteins and enzymes of the Drosophila eggshell matrix. Fakhouri M, et al. Dev Biol, 2006 May 1. PMID 16515779, Free PMC Article
    5. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysteroid metabolic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in ecdysteroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in egg chorion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12398-PA
    NP_572985.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14911781..14913812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132757.2 → NP_572985.1  uncharacterized protein Dmel_CG12398 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY02, U3GXQ6
      Related
      FBpp0073793
      Conserved Domains (3) summary
      PRK02106
      Location:55 → 632
      PRK02106; choline dehydrogenase; Validated
      pfam05199
      Location:472 → 615
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:129 → 354
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY02 Q9VY02

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