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    CG7408 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7408provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036765
    Locus tag
    Dmel_CG7408
    See related
    AllianceGenome:FB:FBgn0036765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7408
    Summary
    Predicted to enable sulfuric ester hydrolase activity. Involved in defense response to bacterium. Is expressed in adult head. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); ARSI (arylsulfatase family member I); and ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7408 in Genome Data Viewer
    Location:
    75A7-75A8; 3-45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17879096..17883653)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17872196..17876753)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. There are two distinct arylsulfatase activities in Drosophila. Pelliccia JG, et al. Biochem Genet, 1987 Aug. PMID 3447585
    2. How Many Parameters Does It Take to Describe Disease Tolerance? Louie A, et al. PLoS Biol, 2016 Apr. PMID 27088212, Free PMC Article
    3. The Exon Junction Complex and intron removal prevent re-splicing of mRNA. Joseph B, et al. PLoS Genet, 2021 May. PMID 34033644, Free PMC Article
    4. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article
    5. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7408-PB
    CG7408-PC
    CG7408-PD
    NP_001163462.1
    NP_001163463.1
    NP_649020.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17879096..17883653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140763.2 → NP_649020.1  uncharacterized protein Dmel_CG7408, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVM1
      Related
      FBpp0074908
      Conserved Domains (2) summary
      COG3119
      Location:31 → 425
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:35 → 423
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

    2. NM_001169991.2 → NP_001163462.1  uncharacterized protein Dmel_CG7408, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVM1
      Conserved Domains (2) summary
      COG3119
      Location:31 → 425
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:35 → 423
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

    3. NM_001169992.2 → NP_001163463.1  uncharacterized protein Dmel_CG7408, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVM1
      Conserved Domains (2) summary
      COG3119
      Location:31 → 425
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:35 → 423
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS40 Q8MS40
    Q9VVM1 Q9VVM1

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