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    Tsp74F Tetraspanin 74F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp74Fprovided by FlyBase
    Official Full Name
    Tetraspanin 74Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036769
    Locus tag
    Dmel_CG5492
    See related
    AllianceGenome:FB:FBgn0036769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5492; Dm.Tsp74F; Dmel\CG5492; tsp74F
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; egg chamber; embryonic anal pad; embryonic epipharynx; and gut section. Orthologous to human TSPAN11 (tetraspanin 11) and TSPAN16 (tetraspanin 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp74F in Genome Data Viewer
    Location:
    75A8-75A8; 3-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17891820..17895862, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17884920..17888962, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene prestin Neighboring gene WD repeat domain 92 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization. Han SY, et al. FEBS Lett, 2012 Nov 16. PMID 23068610
    2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    3. Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila. Adewoye AB, et al. J Biol Rhythms, 2017 Oct. PMID 28990443
    4. Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation. Podolsky MJ, et al. Am J Physiol Lung Cell Mol Physiol, 2018 Sep 1. PMID 29792348, Free PMC Article
    5. Discovering human diabetes-risk gene function with genetics and physiological assays. Peiris H, et al. Nat Commun, 2018 Sep 21. PMID 30242153, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Tsp66E and Tsp74F mutant ovaries had elevated inflated gene product alphaPS2 integrin levels and reduced endocytic trafficking.
      Title: Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 74F
    Names
    CG5492-PA
    CG5492-PB
    Tetraspanin74F
    Tsp74F-PA
    Tsp74F-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17891820..17895862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168754.3 → NP_730317.1  tetraspanin 74F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZI2
      Related
      FBpp0074920
      Conserved Domains (1) summary
      pfam00335
      Location:14 → 231
      Tetraspannin; Tetraspanin family

    2. NM_079408.6 → NP_524132.1  tetraspanin 74F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZI2
      Related
      FBpp0074921
      Conserved Domains (1) summary
      pfam00335
      Location:14 → 231
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZI2 Q7JZI2

    Gene LinkOut

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