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    Ctr1B Copper transporter 1B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctr1Bprovided by FlyBase
    Official Full Name
    Copper transporter 1Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0062412
    Locus tag
    Dmel_CG7459
    See related
    AllianceGenome:FB:FBgn0062412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7459; ctr1B; Dmel\CG7459
    Summary
    Enables copper ion transmembrane transporter activity. Involved in copper ion transport; intracellular copper ion homeostasis; and response to metal ion. Predicted to be located in membrane. Is expressed in adult heart; embryonic hindgut; embryonic midgut chamber; embryonic/larval midgut; and yolk nucleus. Used to study Wilson disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ctr1B in Genome Data Viewer
    Location:
    84F11-84F11; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8317612..8319205)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4143334..4144927)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45215 Neighboring gene Coenzyme Q biosynthesis protein 2 Neighboring gene Pox meso Neighboring gene Odorant receptor 85a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food. Balamurugan K, et al. Biol Chem, 2009 Feb. PMID 19040355
    2. Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila. Hua H, et al. Biometals, 2011 Jun. PMID 21465178
    3. Detection of genetically altered copper levels in Drosophila tissues by synchrotron x-ray fluorescence microscopy. Lye JC, et al. PLoS One, 2011. PMID 22053217, Free PMC Article
    4. The Drosophila copper transporter Ctr1C functions in male fertility. Steiger D, et al. J Biol Chem, 2010 May 28. PMID 20351114, Free PMC Article
    5. Mottled Mice and Non-Mammalian Models of Menkes Disease. Lenartowicz M, et al. Front Mol Neurosci, 2015. PMID 26732058, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using a model of HD, we found that altered expression of Ctr1B or ATP7 in the brain, or modulation of dietary copper availability, significantly modified the phenotypes caused by human Htt exon1-polyQ expression.
      Title: Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.
    2. Data indicate that MTF-1 is capable of binding to different regions of MtnA and Ctr1b genes depending on different metal stimulation.
      Title: Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation.
    3. Here, it is reported that mutant flies lacking Ctr1B are extremely sensitive to cadmium and mercury treatment, but can be rescued by excess copper in the food.
      Title: Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food.
    4. copper acquisition through the Drosophila Ctr1B transporter is crucial for normal growth and in early and specific stages of metazoan development
      Title: A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    copper transporter 1B
    Names
    CG7459-PA
    Ctr1B-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8317612..8319205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141533.4 → NP_649790.1  copper transporter 1B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4K7U3, Q9VHS6
      Related
      FBpp0081325
      Conserved Domains (1) summary
      pfam04145
      Location:17 → 160
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHS6 Q9VHS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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