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    Nha2 Na[+]/H[+] hydrogen antiporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nha2provided by FlyBase
    Official Full Name
    Na[+]/H[+] hydrogen antiporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0263390
    Locus tag
    Dmel_CG43442
    See related
    AllianceGenome:FB:FBgn0263390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31052; CG43205; CG43442; CG4682; CG4693; Dmel\CG43442; DMG8-chr3R.34.001; DmNHA2; nha2; tango12; Tango12; TANGO12
    Old locus tag
    Dmel_CG31052
    Summary
    Enables sodium:proton antiporter activity and solute:potassium antiporter activity. Involved in potassium ion transmembrane transport; protein secretion; and renal sodium ion transport. Located in Golgi apparatus and brush border. Is expressed in Malpighian tubule; adult head; embryonic large intestine; and hindgut. Orthologous to human SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nha2 in Genome Data Viewer
    Location:
    94D6-94D7; 3-77 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22981459..22998528, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18807181..18824250, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transition protein-like 94D Neighboring gene Growth-blocking peptide 3 Neighboring gene Odorant receptor 94a Neighboring gene Odorant receptor 94b Neighboring gene antisense RNA:CR43454 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Chintapalli VR, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324901, Free PMC Article
    2. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett CL, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15643048
    3. Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Day JP, et al. J Cell Sci, 2008 Aug 1. PMID 18628302
    4. The Drosophila Malpighian tubule as a model for mammalian tubule function. Rodan AR. Curr Opin Nephrol Hypertens, 2019 Sep. PMID 31268918, Free PMC Article
    5. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHA1 and NHA2 are essential for survival, but have distinct transport modalities
      Title: Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
    2. CG31052 is a member of the CPA2 gene family, colocalise to the same apical membrane as the plasma membrane V-ATPase and show distinct ion specificities, as expected for the Wieczorek exchanger.
      Title: Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:potassium antiporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Na[+]/H[+] hydrogen antiporter 2
    Names
    CG43442-PA
    CG43442-PB
    Nha2-PA
    Nha2-PB
    transport and golgi organization 12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22981459..22998528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260322.1 → NP_001247251.1  Na[+]/H[+] hydrogen antiporter 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G5
      Conserved Domains (1) summary
      cl01133
      Location:279 → 686
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_170043.2 → NP_732807.1  Na[+]/H[+] hydrogen antiporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U48, Q9VCS7
      Related
      FBpp0301108
      Conserved Domains (1) summary
      cl01133
      Location:149 → 556
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6G5 A0A0B4K6G5
    Q9VCS7 Q9VCS7

    Gene LinkOut

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