U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SkpA SKP1-related A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31016, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SkpAprovided by FlyBase
    Official Full Name
    SKP1-related Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025637
    Locus tag
    Dmel_CG16983
    See related
    AllianceGenome:FB:FBgn0025637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.234; anon-WO03040301.236; anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1; dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037; l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA; SKPA; spkA
    Summary
    Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including DNA endoreduplication; negative regulation of signal transduction; and positive regulation of cell cycle. Part of SCF ubiquitin ligase complex. Is expressed in adult head; adult heart; and organism. Used to study neurodegenerative disease. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SkpA in Genome Data Viewer
    Location:
    1B14-1B14; 1-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (656114..657899)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (550147..551932)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Histone methyltransferase 4-20 Neighboring gene Regulator of cullins 1a Neighboring gene pseudo Neighboring gene sidekick Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of the Drosophila skpA gene as a novel target of the transcription factor DREF. Phuong Thao DT, et al. Exp Cell Res, 2006 Nov 1. PMID 16962096
    2. Dysregulation of core components of SCF complex in poly-glutamine disorders. Bhutani S, et al. Cell Death Dis, 2012 Nov 22. PMID 23171848, Free PMC Article
    3. Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain. Dabool L, et al. iScience, 2020 Aug 21. PMID 32739834, Free PMC Article
    4. Targeted localized degradation of Paired protein in Drosophila development. Raj L, et al. Curr Biol, 2000 Oct 19. PMID 11069107
    5. Regulation of autophosphorylation controls PLK4 self-destruction and centriole number. Cunha-Ferreira I, et al. Curr Biol, 2013 Nov 18. PMID 24184099

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
      Title: SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
    2. SkpA is a novel regulator of both synaptic development and axonal maintenance.
      Title: SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.
    3. Drosophila morgue associates with SkpA and polyubiquitin in vivo.
      Title: Drosophila morgue associates with SkpA and polyubiquitin in vivo.
    4. The ubiquitin-proteasome pathway and this protein induce the antibacterial peptide, diptericin.
      Title: A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade.
    5. SCF targets regulate the centrosome duplication pathway.
      Title: Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation.
    6. Results indicate that the Drosophila skpA gene is a novel target of the transcription factor DREF.
      Title: Identification of the Drosophila skpA gene as a novel target of the transcription factor DREF.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin ligase complex scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SKP1-related A
    Names
    CG16983-PA
    CG16983-PB
    CG16983-PC
    CG16983-PD
    CG16983-PE
    CG16983-PF
    CG16983-PG
    CG16983-PH
    CG16983-PI
    SCF-betaTrCP complex
    Skp1-related gene A
    SkpA-PA
    SkpA-PB
    SkpA-PC
    SkpA-PD
    SkpA-PE
    SkpA-PF
    SkpA-PG
    SkpA-PH
    SkpA-PI
    skpA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      656114..657899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166858.3 → NP_726692.1  SKP1-related A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070119
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    2. NM_058042.5 → NP_477390.1  SKP1-related A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070118
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    3. NM_001038729.3 → NP_001033818.1  SKP1-related A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    4. NM_166857.3 → NP_726691.1  SKP1-related A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070122
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    5. NM_166856.3 → NP_726690.1  SKP1-related A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070121
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    6. NM_166861.3 → NP_726695.1  SKP1-related A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070120
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    7. NM_166860.3 → NP_726694.1  SKP1-related A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070123
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    8. NM_166859.3 → NP_726693.1  SKP1-related A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Related
      FBpp0070124
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain

    9. NM_001297826.1 → NP_001284755.1  SKP1-related A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77430
      Conserved Domains (2) summary
      cd18322
      Location:4 → 126
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:112 → 159
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77430 O77430

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous