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    Epg5 ectopic P-granules autophagy protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epg5provided by FlyBase
    Official Full Name
    ectopic P-granules autophagy protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038651
    Locus tag
    Dmel_CG14299
    See related
    AllianceGenome:FB:FBgn0038651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14299; Dmel\CG14299; epg5; EPG5
    Summary
    Involved in autophagy. Predicted to be active in cytoplasm. Is expressed in adult head; dorsal head epidermis; gonad; and organism. Used to study Vici syndrome. Human ortholog(s) of this gene implicated in Vici syndrome. Orthologous to human EPG5 (ectopic P-granules 5 autophagy tethering factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Epg5 in Genome Data Viewer
    Location:
    91C6-91C6; 3-64 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18750436..18758873, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14576158..14584595, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphatidylglycerophosphate synthase 1 Neighboring gene greatwall Neighboring gene uncharacterized protein Neighboring gene alpha2-adrenergic-like octopamine receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy. Byrne S, et al. Brain, 2016 Mar. PMID 26917586, Free PMC Article
    2. The role of mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease. Cox RT, et al. Reprod Fertil, 2021 Dec. PMID 35118415, Free PMC Article
    3. Unlimited Genetic Switches for Cell-Type-Specific Manipulation. Garcia-Marques J, et al. Neuron, 2019 Oct 23. PMID 31395429
    4. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
    5. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ectopic P-granules autophagy protein 5
    Names
    CG14299-PC
    CG14299-PD
    Epg5-PC
    Epg5-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18750436..18758873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260255.2 → NP_001247184.1  ectopic P-granules autophagy protein 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6N7

    2. NM_142495.4 → NP_650752.2  ectopic P-granules autophagy protein 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650752.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT53, Q9VE34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6N7 A0A0B4K6N7
    Q9VE34.2 Q9VE34

    Gene LinkOut

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