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    Nep2 Neprilysin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40588, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nep2provided by FlyBase
    Official Full Name
    Neprilysin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027570
    Locus tag
    Dmel_CG9761
    See related
    AllianceGenome:FB:FBgn0027570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07643; CG9761; Dmel\CG9761; DmNEP2; dNEP2; nep2; NEP2
    Summary
    Enables metalloendopeptidase activity. Involved in proteolysis and sperm competition. Located in extracellular space. Is expressed in several structures, including adult brain; epithelium; follicle cell; synaptic neuropil domain; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nep2 in Genome Data Viewer
    Location:
    82D2-82D2; 3-47.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4719458..4731878, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (545180..557600, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit f1 Neighboring gene long non-coding RNA:CR44923 Neighboring gene antisense RNA:CR46137 Neighboring gene transforming acidic coiled-coil protein Neighboring gene mir-9384 stem loop

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    mobile_element

    • Loc: c4722120-4722001 mobile_element_type = transposon:INE-1{}4487

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity PubMed 
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity PubMed 
    enables metallopeptidase activity PubMed 
    Process Evidence Code Pubs
    involved_in protein processing  
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    involved_in sperm competition PubMed 
    Component Evidence Code Pubs
    located_in extracellular space PubMed 
    located_in membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    neprilysin 2
    Names
    CG9761-PA
    CG9761-PB
    CG9761-PC
    Nep2-PA
    Nep2-PB
    Nep2-PC
    neprilysin-2
    NP_001246914.1
    NP_001262260.1
    NP_524227.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4719458..4731878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275331.1 → NP_001262260.1  neprilysin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692
      Conserved Domains (2) summary
      cd08662
      Location:104 → 761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:92 → 763
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    2. NM_079503.4 → NP_524227.1  neprilysin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692
      Related
      FBpp0078531
      Conserved Domains (2) summary
      cd08662
      Location:104 → 761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:92 → 763
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    3. NM_001259985.2 → NP_001246914.1  neprilysin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692, D3DMK4, Q9XZ01
      Conserved Domains (1) summary
      cd08662
      Location:104 → 772
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
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